WHO/IUIS Allergen Nomenclature: Providing a common language

Anna Pomés, Janet M. Davies, Gabriele Gadermaier, Christiane Hilger, Thomas Holzhauser, Jonas Lidholm, Andreas L. Lopata, Geoffrey A. Mueller, Andreas Nandy, Christian Radauer, Sanny K. Chan, Uta Jappe, Jörg Kleine-Tebbe, Wayne R. Thomas, Martin D. Chapman, Marianne van Hage, Ronald van Ree, Stefan Vieths, Monika Raulf, Richard E. Goodman*on behalf of the WHO IUIS Allergen Nomenclature Sub-Committee

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

140 Citations (Scopus)


A systematic nomenclature for allergens originated in the early 1980s, when few protein allergens had been described. A group of scientists led by Dr. David G. Marsh developed a nomenclature based on the Linnaean taxonomy, and further established the World Health Organization/International Union of Immunological Societies (WHO/IUIS) Allergen Nomenclature Sub-Committee in 1986. Its stated aim was to standardize the names given to the antigens (allergens) that caused IgE-mediated allergies in humans. The Sub-Committee first published a revised list of allergen names in 1986, which continued to grow with rare publications until 1994. Between 1994 and 2007 the database was a text table online, then converted to a more readily updated website. The allergen list became the Allergen Nomenclature database (www.allergen.org), which currently includes approximately 880 proteins from a wide variety of sources. The Sub-Committee includes experts on clinical and molecular allergology. They review submissions of allergen candidates, using evidence-based criteria developed by the Sub-Committee. The review process assesses the biochemical analysis and the proof of allergenicity submitted, and aims to assign allergen names prior to publication. The Sub-Committee maintains and revises the database, and addresses continuous challenges as new “omics” technologies provide increasing data about potential new allergens. Most journals publishing information on new allergens require an official allergen name, which involves submission of confidential data to the WHO/IUIS Allergen Nomenclature Sub-Committee, sufficient to demonstrate binding of IgE from allergic subjects to the purified protein.

Original languageEnglish
Pages (from-to)3-13
Number of pages11
JournalMolecular Immunology
Publication statusPublished - Aug 2018


  • Allergen database
  • IgE
  • Isoallergen
  • Taxonomic name
  • WHO/IUIS Allergen Nomenclature


Dive into the research topics of 'WHO/IUIS Allergen Nomenclature: Providing a common language'. Together they form a unique fingerprint.

Cite this