VCCL2/vMIP-II, the viral master KEYmokine

Martyna Szpakowska, Andy Chevigné*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)

Abstract

Viral CC motif chemokine or viral macrophage inflammatory protein-II is 1 of the 3 chemokines encoded by the human herpesvirus-8 to interfere with the host chemokine receptor network, facilitate the immune escape, and promote its survival. Viral CC motif chemokine 2 binds to a broad spectrum of viral and human chemokine receptors of all 4 classes and, depending on the receptor, acts either as n agonist or an antagonist, inducing or blocking the recruitment of specific immune cell subsets. These atypical binding and signaling properties make this viral chemokine not only a useful tool to investigate the complexity of the chemokine–receptor interaction network or the virus–host interplay but also for the development of receptor inhibitors. Thismini-review summarizes the knowledge currently available on viral CC motif chemokine 2 binding, signaling, and structural mimicry and discusses its role and importance for the virus, the therapeutic potential, and the open questions regarding the biology of this fascinating chemokine.

Original languageEnglish
Pages (from-to)893-900
Number of pages8
JournalJournal of Leukocyte Biology
Volume99
Issue number6
DOIs
Publication statusPublished - Jun 2016

Keywords

  • CXCR4 900
  • Chemokine receptor
  • GPCR
  • HHV-8
  • KSHV

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