TY - JOUR
T1 - Various Tastes of Sugar
T2 - The Potential of Glycosylation in Targeting and Modulating Human Immunity via C-Type Lectin Receptors
AU - Busold, Stefanie
AU - Nagy, Noémi A.
AU - Tas, Sander W.
AU - van Ree, Ronald
AU - de Jong, Esther C.
AU - Geijtenbeek, Teunis B.H.
N1 - Publisher Copyright:
© Copyright © 2020 Busold, Nagy, Tas, van Ree, de Jong and Geijtenbeek.
PY - 2020/2/7
Y1 - 2020/2/7
N2 - C-type lectin receptors (CLRs) are important in several immune regulatory processes. These receptors recognize glycans expressed by host cells or by pathogens. Whereas pathogens are recognized through their glycans, which leads to protective immunity, aberrant cellular glycans are now increasingly recognized as disease-driving factors in cancer, auto-immunity, and allergy. The vast variety of glycan structures translates into a wide spectrum of effects on the immune system ranging from immune suppression to hyper-inflammatory responses. CLRs have distinct expression patterns on antigen presenting cells (APCs) controlling their role in immunity. CLRs can also be exploited to selectively target specific APCs, modulate immune responses and enhance antigen presentation. Here we will discuss the role of glycans and their receptors in immunity as well as potential strategies for immune modulation. A special focus will be given to different dendritic cell subsets as these APCs are crucial orchestrators of immune responses in infections, cancer, auto-immunity and allergies. Furthermore, we will highlight the potential use of nanoscale lipid bi-layer structures (liposomes) in targeted immunotherapy.
AB - C-type lectin receptors (CLRs) are important in several immune regulatory processes. These receptors recognize glycans expressed by host cells or by pathogens. Whereas pathogens are recognized through their glycans, which leads to protective immunity, aberrant cellular glycans are now increasingly recognized as disease-driving factors in cancer, auto-immunity, and allergy. The vast variety of glycan structures translates into a wide spectrum of effects on the immune system ranging from immune suppression to hyper-inflammatory responses. CLRs have distinct expression patterns on antigen presenting cells (APCs) controlling their role in immunity. CLRs can also be exploited to selectively target specific APCs, modulate immune responses and enhance antigen presentation. Here we will discuss the role of glycans and their receptors in immunity as well as potential strategies for immune modulation. A special focus will be given to different dendritic cell subsets as these APCs are crucial orchestrators of immune responses in infections, cancer, auto-immunity and allergies. Furthermore, we will highlight the potential use of nanoscale lipid bi-layer structures (liposomes) in targeted immunotherapy.
KW - C-type lectin receptors
KW - glycan vaccines
KW - immunomodulation
KW - immunotherapy
KW - in vivo targeting dendritic cells
KW - protein glycosylation in immunology
UR - http://www.scopus.com/inward/record.url?scp=85079823334&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2020.00134
DO - 10.3389/fimmu.2020.00134
M3 - Review article
C2 - 32117281
AN - SCOPUS:85079823334
SN - 1664-3224
VL - 11
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 134
ER -