Valproic acid

Sébastien Chateauvieux; Franck Morceau; Marc Diederich

doi:10.1016/B978-0-12-824315-2.00578-9

Valproic acid

Sébastien Chateauvieux, Franck Morceau, Marc Diederich

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Valproic acid (VPA) (CAS 1069-66-5) and sodium valproate are widely used as antiepileptic drugs and mood stabilizers. Antiepileptic properties are due to inhibition of gamma-aminobutyrate (GABA) transaminobutyrate and ion channel transport. VPA is implicated in various therapies, witnessed by an increasing number of clinical trials. Besides its epigenetic modulatory effects, this chapter also describes recently investigated molecular mechanisms and essential side effects of VPA.

Original language	English
Title of host publication	Encyclopedia of Toxicology, Fourth Edition
Subtitle of host publication	Volume 1-9
Publisher	Elsevier
Pages	V9-705-V9-713
Volume	9
ISBN (Electronic)	9780128243152
DOIs	https://doi.org/10.1016/B978-0-12-824315-2.00578-9
Publication status	Published - 1 Jan 2023
Externally published	Yes

Keywords

Anticonvulsant
Epigenetics
Hepatotoxicity
Side effects
Teratogenicity
Toxicity
Valproate
Valproic acid

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10.1016/B978-0-12-824315-2.00578-9

Cite this

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abstract = "Valproic acid (VPA) (CAS 1069-66-5) and sodium valproate are widely used as antiepileptic drugs and mood stabilizers. Antiepileptic properties are due to inhibition of gamma-aminobutyrate (GABA) transaminobutyrate and ion channel transport. VPA is implicated in various therapies, witnessed by an increasing number of clinical trials. Besides its epigenetic modulatory effects, this chapter also describes recently investigated molecular mechanisms and essential side effects of VPA.",

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T1 - Valproic acid

AU - Chateauvieux, Sébastien

AU - Morceau, Franck

AU - Diederich, Marc

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AB - Valproic acid (VPA) (CAS 1069-66-5) and sodium valproate are widely used as antiepileptic drugs and mood stabilizers. Antiepileptic properties are due to inhibition of gamma-aminobutyrate (GABA) transaminobutyrate and ion channel transport. VPA is implicated in various therapies, witnessed by an increasing number of clinical trials. Besides its epigenetic modulatory effects, this chapter also describes recently investigated molecular mechanisms and essential side effects of VPA.

KW - Anticonvulsant

KW - Epigenetics

KW - Hepatotoxicity

KW - Side effects

KW - Teratogenicity

KW - Toxicity

KW - Valproate

KW - Valproic acid

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M3 - Chapter

AN - SCOPUS:85188072147

VL - 9

SP - V9-705-V9-713

BT - Encyclopedia of Toxicology, Fourth Edition

PB - Elsevier

ER -

Valproic acid

Abstract

Keywords

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