Valproic Acid

S. Chateauvieux; F. Morceau; M. Diederich

doi:10.1016/B978-0-12-386454-3.00073-7

Valproic Acid

S. Chateauvieux^*, F. Morceau, M. Diederich

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

4 Citations (Scopus)

Abstract

Valproic acid (VPA) (Chemical Abstracts Service Registry Number 1069-66-5) as well as sodium valproate, are widely used as an antiepileptic drug and a mood stabilizer. Antiepileptic properties have been attributed to inhibition of γ-aminobutyrate transaminobutyrate and ion channels. Due to the increasing number of clinical trials involving VPA, the increasing data provided by the literature, and some of the interesting results obtained, this molecule will probably be more and more implicated in various therapies. However, although the side effects triggered by VPA are often described in the specific medical literature, they are poorly discussed in original research articles.

Original language	English
Title of host publication	Encyclopedia of Toxicology
Subtitle of host publication	Third Edition
Publisher	Elsevier
Pages	905-908
Number of pages	4
ISBN (Electronic)	9780123864543
ISBN (Print)	9780123864550
DOIs	https://doi.org/10.1016/B978-0-12-386454-3.00073-7
Publication status	Published - 1 Jan 2014
Externally published	Yes

Keywords

Anticonvulsant
Hepatotoxicity
Side effects
Teratogenicity
Toxicity
Valproate
Valproic

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10.1016/B978-0-12-386454-3.00073-7

Cite this

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title = "Valproic Acid",

abstract = "Valproic acid (VPA) (Chemical Abstracts Service Registry Number 1069-66-5) as well as sodium valproate, are widely used as an antiepileptic drug and a mood stabilizer. Antiepileptic properties have been attributed to inhibition of γ-aminobutyrate transaminobutyrate and ion channels. Due to the increasing number of clinical trials involving VPA, the increasing data provided by the literature, and some of the interesting results obtained, this molecule will probably be more and more implicated in various therapies. However, although the side effects triggered by VPA are often described in the specific medical literature, they are poorly discussed in original research articles.",

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AU - Morceau, F.

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AB - Valproic acid (VPA) (Chemical Abstracts Service Registry Number 1069-66-5) as well as sodium valproate, are widely used as an antiepileptic drug and a mood stabilizer. Antiepileptic properties have been attributed to inhibition of γ-aminobutyrate transaminobutyrate and ion channels. Due to the increasing number of clinical trials involving VPA, the increasing data provided by the literature, and some of the interesting results obtained, this molecule will probably be more and more implicated in various therapies. However, although the side effects triggered by VPA are often described in the specific medical literature, they are poorly discussed in original research articles.

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KW - Hepatotoxicity

KW - Side effects

KW - Teratogenicity

KW - Toxicity

KW - Valproate

KW - Valproic

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EP - 908

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Valproic Acid

Abstract

Keywords

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