Validation et contribution à ĺétude de l'effet antihyperglycémique d'une plante médicinale, le Momordica charantia L.

Translated title of the contribution: A study of the anti-hyperglycaemic effects of the medicinal plant, Momordica charantia L.: Validation and contribution

H. Rammal, J. Bouayed, F. Desor, C. Younos, R. Soulimani*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Momordica charantia (L.) [Cucurbitaceae], more commonly known as the bitter cucumber or bitter melon, is a plant used for food and medicine. In the Ayurvedic tradition it is used to treat a range of disorders, including diabetes. This study has demonstrated the plant's anti-hyperglycaemic effect in mice with alloxan monohydrate induced diabetes. Two extracts were prepared, from both the fresh and the dried fruit of the plant, and their effects on blood sugar levels were compared with the reference anti-diabetes molecule glibenclamide. Aqueous extract of the fresh fruit at a dose of 200 mg/kg demonstrated a significant reduction in glycemia (62%), comparable with that of glibenclamide at a dose of 10 mg/kg. The two extracts at different doses showed no signs of toxicity. Thus, aqueous extract of the edible plant M. charantia would appear to be a viable alternative for reducing glycemia as well as providing an auxiliary and complementary treatment which would limit the secondary effects of allopathic remedies using synthetic drugs.

Translated title of the contributionA study of the anti-hyperglycaemic effects of the medicinal plant, Momordica charantia L.: Validation and contribution
Original languageFrench
Pages (from-to)191-196
Number of pages6
JournalPhytotherapie
Volume7
Issue number4
DOIs
Publication statusPublished - Aug 2009
Externally publishedYes

Keywords

  • Alloxan
  • Anti-hyperglycaemic activity
  • Glibenclamide
  • Mice
  • Momordica charantia

Cite this