Use of coronary ultrasound imaging to evaluate ventricular function in Adult Zebrafish

Isabelle Ernens*, Andrew I. Lumley, Yvan Devaux, Daniel R. Wagner

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

So far, imaging of the adult zebrafish heart and assessment of heart failure in adult zebrafish have been very limited. Here, we describe a new method for in vivo imaging of the hypertrabeculated heart of the adult zebrafish using miniaturized cardiac ultrasound catheters obtained from the cardiac catheterization laboratory. This method allows the observation of the ventricle of zebrafish and the assessment of ventricular diameters during diastole and systole, as well as heart rate and fractional shortening. Significant changes in these parameters were detected through the use of an adult zebrafish heart failure model induced by chronic anemia. This imaging technique opens the door to detailed in vivo analysis of the adult heart failure phenotype in zebrafish.

Original languageEnglish
Pages (from-to)477-480
Number of pages4
JournalZebrafish
Volume13
Issue number6
DOIs
Publication statusPublished - 2016

Keywords

  • adult zebrafish
  • cardiac function
  • heart failure
  • miniaturized ultrasound system

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