TY - JOUR
T1 - Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells
AU - Florido, Javier
AU - Rodriguez-Santana, César
AU - Martinez-Ruiz, Laura
AU - López-Rodríguez, Alba
AU - Acuña-Castroviejo, Darío
AU - Rusanova, Iryna
AU - Escames, Germaine
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/8
Y1 - 2022/8
N2 - Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have evolved as regulators of important signaling pathways. In this context, tumor cells have an altered redox balance compared to normal cells, which can be targeted as an antitumoral therapy by ROS levels and by decreasing the capacity of the antioxidant system, leading to programmed cell death. Melatonin is of particular importance in the development of innovative cancer treatments due to its oncostatic impact and lack of adverse effects. Despite being widely recognized as a pro-oxidant molecule in tumor cells, the mechanism of action of melatonin remains unclear, which has hindered its use in clinical treatments. The current review aims to describe and clarify the proposed mechanism of action of melatonin inducing ROS production in cancer cells in order to propose future anti-neoplastic clinical applications.
AB - Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have evolved as regulators of important signaling pathways. In this context, tumor cells have an altered redox balance compared to normal cells, which can be targeted as an antitumoral therapy by ROS levels and by decreasing the capacity of the antioxidant system, leading to programmed cell death. Melatonin is of particular importance in the development of innovative cancer treatments due to its oncostatic impact and lack of adverse effects. Despite being widely recognized as a pro-oxidant molecule in tumor cells, the mechanism of action of melatonin remains unclear, which has hindered its use in clinical treatments. The current review aims to describe and clarify the proposed mechanism of action of melatonin inducing ROS production in cancer cells in order to propose future anti-neoplastic clinical applications.
KW - apoptosis
KW - cancer
KW - melatonin
KW - mitochondria
KW - reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=85137325447&partnerID=8YFLogxK
U2 - 10.3390/antiox11081621
DO - 10.3390/antiox11081621
M3 - Review article
AN - SCOPUS:85137325447
SN - 2076-3921
VL - 11
JO - Antioxidants
JF - Antioxidants
IS - 8
M1 - 1621
ER -