TY - JOUR
T1 - Understanding gene functions and disease mechanisms
T2 - Phenotyping pipelines in the German Mouse Clinic
AU - Fuchs, Helmut
AU - Aguilar-Pimentel, Juan Antonio
AU - Amarie, Oana V.
AU - Becker, Lore
AU - Calzada-Wack, Julia
AU - Cho, Yi Li
AU - Garrett, Lillian
AU - Hölter, Sabine M.
AU - Irmler, Martin
AU - Kistler, Martin
AU - Kraiger, Markus
AU - Mayer-Kuckuk, Philipp
AU - Moreth, Kristin
AU - Rathkolb, Birgit
AU - Rozman, Jan
AU - da Silva Buttkus, Patricia
AU - Treise, Irina
AU - Zimprich, Annemarie
AU - Gampe, Kristine
AU - Hutterer, Christine
AU - Stöger, Claudia
AU - Leuchtenberger, Stefanie
AU - Maier, Holger
AU - Miller, Manuel
AU - Scheideler, Angelika
AU - Wu, Moya
AU - Beckers, Johannes
AU - Bekeredjian, Raffi
AU - Brielmeier, Markus
AU - Busch, Dirk H.
AU - Klingenspor, Martin
AU - Klopstock, Thomas
AU - Ollert, Markus
AU - Schmidt-Weber, Carsten
AU - Stöger, Tobias
AU - Wolf, Eckhard
AU - Wurst, Wolfgang
AU - Yildirim, Ali Önder
AU - Zimmer, Andreas
AU - Gailus-Durner, Valérie
AU - Hrabě de Angelis, Martin
N1 - Funding Information:
The GMC is funded by the German Federal Ministry of Education and Research (Infrafrontier grant 01KX1012), the German Center for Diabetes Research (DZD), the German Center for Vertigo and Balance Disorders (grant 01 EO 0901), the Helmholtz Portfolio Theme ?Metabolic Dysfunction and Common Disease? and by the Helmholtz Alliance ?Imaging and Curing Environmental Metabolic Disease ?ICEMED?.
Funding Information:
The GMC is funded by the German Federal Ministry of Education and Research (Infrafrontier grant 01KX1012 ), the German Center for Diabetes Research (DZD) , the German Center for Vertigo and Balance Disorders (grant 01 EO 0901 ), the Helmholtz Portfolio Theme “Metabolic Dysfunction and Common Disease” and by the Helmholtz Alliance “Imaging and Curing Environmental Metabolic Disease ‘ICEMED’ .
Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2018/10/15
Y1 - 2018/10/15
N2 - Since decades, model organisms have provided an important approach for understanding the mechanistic basis of human diseases. The German Mouse Clinic (GMC) was the first phenotyping facility that established a collaboration-based platform for phenotype characterization of mouse lines. In order to address individual projects by a tailor-made phenotyping strategy, the GMC advanced in developing a series of pipelines with tests for the analysis of specific disease areas. For a general broad analysis, there is a screening pipeline that covers the key parameters for the most relevant disease areas. For hypothesis-driven phenotypic analyses, there are thirteen additional pipelines with focus on neurological and behavioral disorders, metabolic dysfunction, respiratory system malfunctions, immune-system disorders and imaging techniques. In this article, we give an overview of the pipelines and describe the scientific rationale behind the different test combinations.
AB - Since decades, model organisms have provided an important approach for understanding the mechanistic basis of human diseases. The German Mouse Clinic (GMC) was the first phenotyping facility that established a collaboration-based platform for phenotype characterization of mouse lines. In order to address individual projects by a tailor-made phenotyping strategy, the GMC advanced in developing a series of pipelines with tests for the analysis of specific disease areas. For a general broad analysis, there is a screening pipeline that covers the key parameters for the most relevant disease areas. For hypothesis-driven phenotypic analyses, there are thirteen additional pipelines with focus on neurological and behavioral disorders, metabolic dysfunction, respiratory system malfunctions, immune-system disorders and imaging techniques. In this article, we give an overview of the pipelines and describe the scientific rationale behind the different test combinations.
KW - Gene function analysis
KW - Mouse model
KW - Mouse phenotyping
KW - Phenotyping pipeline
UR - http://www.scopus.com/inward/record.url?scp=85033471384&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/28966146
U2 - 10.1016/j.bbr.2017.09.048
DO - 10.1016/j.bbr.2017.09.048
M3 - Review article
C2 - 28966146
AN - SCOPUS:85033471384
SN - 0166-4328
VL - 352
SP - 187
EP - 196
JO - Behavioural Brain Research
JF - Behavioural Brain Research
ER -