Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic

Helmut Fuchs, Juan Antonio Aguilar-Pimentel, Oana V. Amarie, Lore Becker, Julia Calzada-Wack, Yi Li Cho, Lillian Garrett, Sabine M. Hölter, Martin Irmler, Martin Kistler, Markus Kraiger, Philipp Mayer-Kuckuk, Kristin Moreth, Birgit Rathkolb, Jan Rozman, Patricia da Silva Buttkus, Irina Treise, Annemarie Zimprich, Kristine Gampe, Christine HuttererClaudia Stöger, Stefanie Leuchtenberger, Holger Maier, Manuel Miller, Angelika Scheideler, Moya Wu, Johannes Beckers, Raffi Bekeredjian, Markus Brielmeier, Dirk H. Busch, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Carsten Schmidt-Weber, Tobias Stöger, Eckhard Wolf, Wolfgang Wurst, Ali Önder Yildirim, Andreas Zimmer, Valérie Gailus-Durner, Martin Hrabě de Angelis*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

Since decades, model organisms have provided an important approach for understanding the mechanistic basis of human diseases. The German Mouse Clinic (GMC) was the first phenotyping facility that established a collaboration-based platform for phenotype characterization of mouse lines. In order to address individual projects by a tailor-made phenotyping strategy, the GMC advanced in developing a series of pipelines with tests for the analysis of specific disease areas. For a general broad analysis, there is a screening pipeline that covers the key parameters for the most relevant disease areas. For hypothesis-driven phenotypic analyses, there are thirteen additional pipelines with focus on neurological and behavioral disorders, metabolic dysfunction, respiratory system malfunctions, immune-system disorders and imaging techniques. In this article, we give an overview of the pipelines and describe the scientific rationale behind the different test combinations.

Original languageEnglish
Pages (from-to)187-196
Number of pages10
JournalBehavioural Brain Research
Volume352
DOIs
Publication statusPublished - 15 Oct 2018

Keywords

  • Gene function analysis
  • Mouse model
  • Mouse phenotyping
  • Phenotyping pipeline

Fingerprint

Dive into the research topics of 'Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic'. Together they form a unique fingerprint.

Cite this