TY - JOUR
T1 - Transmission of Type 2 diabetes to sons and daughters
T2 - the D.E.S.I.R. cohort
AU - Balkau, B.
AU - Roussel, R.
AU - Wagner, S.
AU - Tichet, J.
AU - Froguel, P.
AU - Fagherazzi, G.
AU - Bonnet, F.
AU - for the D.E.S.I.R. Study Group
N1 - Funding Information:
No funding for the present study. The D.E.S.I.R. study has been funded by INSERM contracts with Caisse nationale de l’assurance maladie des travailleurs salaries (CNAMTS), Lilly, Novartis Pharma, and sanofi-aventis; INSERM (Reseaux en Sante Publique, Interactions entre les determinants de la sante, Cohortes Sante TGIR 2008); the Association Diabete Risque Vasculaire; the Federation Francaise de Cardiologie; La Fondation de France; Association de Langue Francaise pour l’Etude du Diabete et des Maladies Metabo-liques (ALFEDIAM)/Societe Francophone de Diabetologie (SFD); l’Office national interprofessionnel des vins (ONI-VINS); Ardix Medical; Bayer Diagnostics; Becton Dickinson; Cardionics; Merck Sante; Novo Nordisk; Pierre Fabre; Roche; Topcon.
Publisher Copyright:
© 2017 Diabetes UK
PY - 2017/11
Y1 - 2017/11
N2 - Aims: To document the family transmission of Type 2 diabetes to men and women. Method: The French D.E.S.I.R. cohort followed men and women over 9 years, with 3-yearly testing for incident Type 2 diabetes. First- and/or second-degree family histories of diabetes were available for 2187 men and 2282 women. Age-adjusted hazard ratios were estimated for various family members and groupings of family members, as well as for a genetic diabetes risk score, based on 65 diabetes-associated loci. Results: Over 9 years, 136 men and 63 women had incident Type 2 diabetes. The hazard ratios for diabetes associated with having a first-degree family member with diabetes (parents, siblings, children) differed between men [1.21 (95% CI 0.80, 1.85)] and women [3.02 (95% CI 1.83, 4.99); Pinteraction=0.006]. The genetic risk score was predictive of diabetes in both men and women, with similar hazard ratios 1.10 (95% CI 1.06, 1.15) and 1.08 (95% CI 1.02, 1.14) respectively, for each additional at-risk allele. In women, the risk associated with having a family member with diabetes persisted after adjusting for the genetic score. Conclusion: Women with a family history of diabetes (paternal or maternal) were at risk of developing Type 2 diabetes and this risk was independent of a genetic score; in contrast, for men, there was no association. Diabetes screening and prevention may need to more specifically target women with diabetes in their family, but further studies are required as the number of people with diabetes in this study was small.
AB - Aims: To document the family transmission of Type 2 diabetes to men and women. Method: The French D.E.S.I.R. cohort followed men and women over 9 years, with 3-yearly testing for incident Type 2 diabetes. First- and/or second-degree family histories of diabetes were available for 2187 men and 2282 women. Age-adjusted hazard ratios were estimated for various family members and groupings of family members, as well as for a genetic diabetes risk score, based on 65 diabetes-associated loci. Results: Over 9 years, 136 men and 63 women had incident Type 2 diabetes. The hazard ratios for diabetes associated with having a first-degree family member with diabetes (parents, siblings, children) differed between men [1.21 (95% CI 0.80, 1.85)] and women [3.02 (95% CI 1.83, 4.99); Pinteraction=0.006]. The genetic risk score was predictive of diabetes in both men and women, with similar hazard ratios 1.10 (95% CI 1.06, 1.15) and 1.08 (95% CI 1.02, 1.14) respectively, for each additional at-risk allele. In women, the risk associated with having a family member with diabetes persisted after adjusting for the genetic score. Conclusion: Women with a family history of diabetes (paternal or maternal) were at risk of developing Type 2 diabetes and this risk was independent of a genetic score; in contrast, for men, there was no association. Diabetes screening and prevention may need to more specifically target women with diabetes in their family, but further studies are required as the number of people with diabetes in this study was small.
UR - http://www.scopus.com/inward/record.url?scp=85031501604&partnerID=8YFLogxK
U2 - 10.1111/dme.13446
DO - 10.1111/dme.13446
M3 - Article
C2 - 28792638
AN - SCOPUS:85031501604
SN - 0742-3071
VL - 34
SP - 1615
EP - 1622
JO - Diabetic Medicine
JF - Diabetic Medicine
IS - 11
ER -