TY - JOUR
T1 - Transmission of drug-resistant HIV-1 is stabilizing in Europe
AU - Vercauteren, Jurgen
AU - Wensing, Annemarie M.J.
AU - Van De Vijver, David A.M.C.
AU - Albert, Jan
AU - Balotta, Claudia
AU - Hamouda, Osamah
AU - Kücherer, Claudia
AU - Struck, Daniel
AU - Schmit, Jean Claude
AU - Åsjö, Birgitta
AU - Bruckova, Marie
AU - Camacho, Ricardo J.
AU - Clotet, Bonaventura
AU - Coughlan, Suzie
AU - Grossman, Zehava
AU - Horban, Andrzej
AU - Korn, Klaus
AU - Kostrikis, Leondios
AU - Nielsen, Claus
AU - Paraskevis, Dimitrios
AU - Poljak, Mario
AU - Puchhammer-Stöckl, Elisabeth
AU - Riva, Chiara
AU - Ruiz, Lidia
AU - Salminen, Mika
AU - Schuurman, Rob
AU - Sonnerborg, Anders
AU - Stanekova, Danica
AU - Stanojevic, Maja
AU - Vandamme, Anne Mieke
AU - Boucher, Charles A.B.
N1 - Funding Information:
Financial support: European Commission (grant QLK2-CT-2001-01344, fifth framework; grant LSHP-CT-2006-518211, sixth framework); Belgian AIDS Reference Laboratory Fund, Belgian Fonds voor Wetenschappelijk Onderzoek (grant G.0611.09); Interuniversitaire Attractiepolen (Belgium; grant P6/41); Cyprus Research Promotion Foundation (grant Health/0104/22); Danish AIDS Foundation; Ministry of Health (Germany; grant 1502-686-18); Ministry of Education and Research (Germany; grant 01KI501); Fifth National Program on HIV/AIDS, Istituto Superiore di Sanità (Italy; grants N 40F.56 and 20D.1.6); Fondation Recherche sur le SiDA; Ministry of Health (Luxembourg); Swedish Research Council; Maraton TV3 Fundation (Spain; grant 02-1730); Ministry of Science Technology and Development (Republic of Serbia; grant 145047).
PY - 2009/11
Y1 - 2009/11
N2 - The SPREAD Programme investigated prospectively the time trend from September 2002 through December 2005 of transmitted drug resistance (TDR) among 2793 patients in 20 European countries and in Israel with newly diagnosed human immunodeficiency virus type 1 (HIV-1) infection. The overall prevalence of TDR was 8.4% (225 of 2687 patients; 95% confidence interval [CI], 7.4%-9.5%), the prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) resistance was 4.7% (125 of 2687 patients; 95% CI, 3.9%-5.5%), the prevalence of nonucleoside reverse-transcriptase inhibitor (NNRTI) resistance was 2.3% (62 of 2687 patients; 95% CI, 1.8%-2.9%), and the prevalence of protease inhibitor (PI) resistance was 2.9% (79 of 2687 patients; 95% CI, 2.4%-3.6%). There was no time trend in the overall TDR or in NRTI resistance, but there was a statistically significant decrease in PI resistance (Pp.04) and in NNRTI resistance after an initial increase (Pp.02). We found that TDR appears to be stabilizing in Europe, consistent with recent reports of decreasing drug resistance and improved viral suppression in patients treated for HIV-1 infection.
AB - The SPREAD Programme investigated prospectively the time trend from September 2002 through December 2005 of transmitted drug resistance (TDR) among 2793 patients in 20 European countries and in Israel with newly diagnosed human immunodeficiency virus type 1 (HIV-1) infection. The overall prevalence of TDR was 8.4% (225 of 2687 patients; 95% confidence interval [CI], 7.4%-9.5%), the prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) resistance was 4.7% (125 of 2687 patients; 95% CI, 3.9%-5.5%), the prevalence of nonucleoside reverse-transcriptase inhibitor (NNRTI) resistance was 2.3% (62 of 2687 patients; 95% CI, 1.8%-2.9%), and the prevalence of protease inhibitor (PI) resistance was 2.9% (79 of 2687 patients; 95% CI, 2.4%-3.6%). There was no time trend in the overall TDR or in NRTI resistance, but there was a statistically significant decrease in PI resistance (Pp.04) and in NNRTI resistance after an initial increase (Pp.02). We found that TDR appears to be stabilizing in Europe, consistent with recent reports of decreasing drug resistance and improved viral suppression in patients treated for HIV-1 infection.
UR - http://www.scopus.com/inward/record.url?scp=70449723682&partnerID=8YFLogxK
U2 - 10.1086/644505
DO - 10.1086/644505
M3 - Article
C2 - 19835478
AN - SCOPUS:70449723682
SN - 0022-1899
VL - 200
SP - 1503
EP - 1508
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 10
ER -