Translocation t(6;7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking

Dieter Weichenhan; Anna Riedel; Charlotte Meinen; Alisa Basic; Reka Toth; Marion Bähr; Pavlo Lutsik; Joschka Hey; Etienne Sollier; Umut H. Toprak; Simge Kelekçi; Yu Yu Lin; Mariam Hakobyan; Aurore Touzart; Ashish Goyal; Justyna A. Wierzbinska; Matthias Schlesner; Frank Westermann; Daniel B. Lipka; Christoph Plass

doi:10.1038/s41375-023-01865-5

Translocation t(6;7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking

Dieter Weichenhan, Anna Riedel, Charlotte Meinen, Alisa Basic, Reka Toth, Marion Bähr, Pavlo Lutsik, Joschka Hey, Etienne Sollier, Umut H. Toprak, Simge Kelekçi, Yu Yu Lin, Mariam Hakobyan, Aurore Touzart, Ashish Goyal, Justyna A. Wierzbinska, Matthias Schlesner, Frank Westermann, Daniel B. Lipka, Christoph Plass^*

^*Corresponding author for this work

Multiomics Data Science

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Original language	English
Pages (from-to)	1147-1150
Number of pages	4
Journal	Leukemia
Volume	37
Issue number	5
Early online date	22 Mar 2023
DOIs	https://doi.org/10.1038/s41375-023-01865-5
Publication status	Published - May 2023

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Weichenhan, D., Riedel, A., Meinen, C., Basic, A., Toth, R., Bähr, M., Lutsik, P., Hey, J., Sollier, E., Toprak, U. H., Kelekçi, S., Lin, Y. Y., Hakobyan, M., Touzart, A., Goyal, A., Wierzbinska, J. A., Schlesner, M., Westermann, F., Lipka, D. B., & Plass, C. (2023). Translocation t(6;7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking. Leukemia, 37(5), 1147-1150. https://doi.org/10.1038/s41375-023-01865-5

@article{5554602f6bab4a53837ed0f63becba7a,

title = "Translocation t(6;7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking",

author = "Dieter Weichenhan and Anna Riedel and Charlotte Meinen and Alisa Basic and Reka Toth and Marion B{\"a}hr and Pavlo Lutsik and Joschka Hey and Etienne Sollier and Toprak, {Umut H.} and Simge Kelek{\c c}i and Lin, {Yu Yu} and Mariam Hakobyan and Aurore Touzart and Ashish Goyal and Wierzbinska, {Justyna A.} and Matthias Schlesner and Frank Westermann and Lipka, {Daniel B.} and Christoph Plass",

note = "Funding Information: We thank Dr. Peter Krijger from the University Medical Center Utrecht for his excellent advice in the use of the pipe4C software. Furthermore, we thank the Genomics and Proteomics Core Facility and the Omics IT and Data Management Core Facility of the DKFZ Heidelberg for their excellent support in DNA and RNA sequencing and analyses. JH and MH were supported by the German-Israeli Helmholtz International Research School: Cancer-TRAX (HIRS-0003), a grant from the Helmholtz Association{\textquoteright}s Initiative and Networking Fund. The work was supported in part by the Helmholtz International Graduate School (AR, MH) and in part by the Deutsche Forschungsgemeinschaft (DFG) funded Sonderforschungsbereich SFB 1074 (CP, AR), the Jos{\'e} Carreras Foundation (CP, ES) and FOR2674 (CP, AG, DBL). ",

year = "2023",

month = may,

doi = "10.1038/s41375-023-01865-5",

language = "English",

volume = "37",

pages = "1147--1150",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Springer Nature",

number = "5",

}

Weichenhan, D, Riedel, A, Meinen, C, Basic, A, Toth, R, Bähr, M, Lutsik, P, Hey, J, Sollier, E, Toprak, UH, Kelekçi, S, Lin, YY, Hakobyan, M, Touzart, A, Goyal, A, Wierzbinska, JA, Schlesner, M, Westermann, F, Lipka, DB & Plass, C 2023, 'Translocation t(6;7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking', Leukemia, vol. 37, no. 5, pp. 1147-1150. https://doi.org/10.1038/s41375-023-01865-5

TY - JOUR

T1 - Translocation t(6;7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking

AU - Weichenhan, Dieter

AU - Riedel, Anna

AU - Meinen, Charlotte

AU - Basic, Alisa

AU - Toth, Reka

AU - Bähr, Marion

AU - Lutsik, Pavlo

AU - Hey, Joschka

AU - Sollier, Etienne

AU - Toprak, Umut H.

AU - Kelekçi, Simge

AU - Lin, Yu Yu

AU - Hakobyan, Mariam

AU - Touzart, Aurore

AU - Goyal, Ashish

AU - Wierzbinska, Justyna A.

AU - Schlesner, Matthias

AU - Westermann, Frank

AU - Lipka, Daniel B.

AU - Plass, Christoph

N1 - Funding Information: We thank Dr. Peter Krijger from the University Medical Center Utrecht for his excellent advice in the use of the pipe4C software. Furthermore, we thank the Genomics and Proteomics Core Facility and the Omics IT and Data Management Core Facility of the DKFZ Heidelberg for their excellent support in DNA and RNA sequencing and analyses. JH and MH were supported by the German-Israeli Helmholtz International Research School: Cancer-TRAX (HIRS-0003), a grant from the Helmholtz Association’s Initiative and Networking Fund. The work was supported in part by the Helmholtz International Graduate School (AR, MH) and in part by the Deutsche Forschungsgemeinschaft (DFG) funded Sonderforschungsbereich SFB 1074 (CP, AR), the José Carreras Foundation (CP, ES) and FOR2674 (CP, AG, DBL).

PY - 2023/5

Y1 - 2023/5

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UR - https://pubmed.ncbi.nlm.nih.gov/36949154

U2 - 10.1038/s41375-023-01865-5

DO - 10.1038/s41375-023-01865-5

M3 - Article

C2 - 36949154

AN - SCOPUS:85150734488

SN - 0887-6924

VL - 37

SP - 1147

EP - 1150

JO - Leukemia

JF - Leukemia

IS - 5

ER -

Translocation t(6;7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking

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