TY - JOUR
T1 - Transgenerational impacts of early life adversity
T2 - from health determinants, implications to epigenetic consequences
AU - Holuka, Cyrielle
AU - Grova, Nathalie
AU - Charalambous, Eleftheria G.
AU - Le Cléac`H, Jeanne
AU - Turner, Jonathan D.
AU - Mposhi, Archibold
N1 - Funding
AM and JDT are funded by the Fonds National de Recherche (FNR) Luxembourg, grant C20/BM/14766620 “ImmunoTwin”. JDT and CH, are funded by the Fonds National de la Recherche (FNR) Luxembourg, grant C19/SC/13650569 ‘ALAC’. JDT is a management board member of the EU-funded COST actions CA18211.
Publisher Copyright:
© 2024 The Authors
PY - 2024/9
Y1 - 2024/9
N2 - Exposure to different environmental factors, social and socioeconomic factors promotes development of the early-life adversity (ELA) phenotype. The persistence of this phenotype across generations is an interesting phenomenon that remains unexplored. Of late many studies have focused on disease-associated outcomes of ELA following exposure during childhood but the persistence of epigenetic imprints transmitted by ELA exposed parents to their offspring remains poorly described. It is possible that both parents are able to transmit ELA-associated genetic imprints to their offspring via transgenerational inheritance mechanisms. Here, we highlight the role of the mother and father in the biological process of conception, from epigenetic reprogramming cycles to later environmental exposures. We explain some of the known determinants of ELA (pollution, socioeconomic challenges, infections, etc.) and their disease-associated outcomes. Finally, we highlight the role of epigenetics, mitochondria and ncRNAs as mechanisms mediating transgenerational inheritance. Whether these transgenerational inheritance mechanisms occur in the human context remains unclear but there is a large body of suggestive evidence in non-human models that points out to its existence.
AB - Exposure to different environmental factors, social and socioeconomic factors promotes development of the early-life adversity (ELA) phenotype. The persistence of this phenotype across generations is an interesting phenomenon that remains unexplored. Of late many studies have focused on disease-associated outcomes of ELA following exposure during childhood but the persistence of epigenetic imprints transmitted by ELA exposed parents to their offspring remains poorly described. It is possible that both parents are able to transmit ELA-associated genetic imprints to their offspring via transgenerational inheritance mechanisms. Here, we highlight the role of the mother and father in the biological process of conception, from epigenetic reprogramming cycles to later environmental exposures. We explain some of the known determinants of ELA (pollution, socioeconomic challenges, infections, etc.) and their disease-associated outcomes. Finally, we highlight the role of epigenetics, mitochondria and ncRNAs as mechanisms mediating transgenerational inheritance. Whether these transgenerational inheritance mechanisms occur in the human context remains unclear but there is a large body of suggestive evidence in non-human models that points out to its existence.
KW - DNA methylation
KW - Early-life adversity
KW - Epigenetics
KW - Mitochondria
KW - non-coding RNAs
KW - Transgenerational inheritance
UR - http://www.scopus.com/inward/record.url?scp=85197576903&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/38945418/
U2 - 10.1016/j.neubiorev.2024.105785
DO - 10.1016/j.neubiorev.2024.105785
M3 - Review article
C2 - 38945418
AN - SCOPUS:85197576903
SN - 0149-7634
VL - 164
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
M1 - 105785
ER -