TY - JOUR
T1 - Transcranial ultrasound in different monogenetic subtypes of Parkinson's disease
AU - Schweitzer, Katherine J.
AU - Brüssel, Theresa
AU - Leitner, Petra
AU - Krüger, Rejko
AU - Bauer, Peter
AU - Woitalla, Dirk
AU - Tomiuk, Jürgen
AU - Gasser, Thomas
AU - Berg, Daniela
PY - 2007/5
Y1 - 2007/5
N2 - Hyperechogenicity of the substantia nigra (SN) has been found to be a typical sign in idiopathic Parkinson's disease (PD), prevalent in more than 90% of affected individuals. To see whether SN hyperechogenicity is also characteristic for monogenetically caused PD, we investigated PD patients with alpha-synuclein, LRRK2, parkin, PINK1 and DJ-1 mutations by transcranial sonography (TCS). In all these patients the area of SN echogenicity was significantly larger than in healthy controls, but smaller, than in idiopathic PD. As SN hyperechogenicity could be related to an increased iron content of the SN, these findings suggest that iron may play a less significant role in the pathogenesis of monogenetically caused compared to idiopathic PD.
AB - Hyperechogenicity of the substantia nigra (SN) has been found to be a typical sign in idiopathic Parkinson's disease (PD), prevalent in more than 90% of affected individuals. To see whether SN hyperechogenicity is also characteristic for monogenetically caused PD, we investigated PD patients with alpha-synuclein, LRRK2, parkin, PINK1 and DJ-1 mutations by transcranial sonography (TCS). In all these patients the area of SN echogenicity was significantly larger than in healthy controls, but smaller, than in idiopathic PD. As SN hyperechogenicity could be related to an increased iron content of the SN, these findings suggest that iron may play a less significant role in the pathogenesis of monogenetically caused compared to idiopathic PD.
KW - Monogenetic PD
KW - Substantia nigra
KW - Transcranial sonography
UR - http://www.scopus.com/inward/record.url?scp=34249107672&partnerID=8YFLogxK
U2 - 10.1007/s00415-006-0369-7
DO - 10.1007/s00415-006-0369-7
M3 - Article
C2 - 17415511
AN - SCOPUS:34249107672
SN - 0340-5354
VL - 254
SP - 613
EP - 616
JO - Journal of Neurology
JF - Journal of Neurology
IS - 5
ER -