TY - JOUR
T1 - Toxic trace elements in maternal and cord blood and social determinants in a Bolivian mining city
AU - Barbieri, Flavia L.
AU - Gardon, Jacques
AU - Ruiz-Castell, María
AU - Paco V., Pamela
AU - Muckelbauer, Rebecca
AU - Casiot, Corinne
AU - Freydier, Rémi
AU - Duprey, Jean Louis
AU - Chen, Chih Mei
AU - Müller-Nordhorn, Jacqueline
AU - Keil, Thomas
N1 - Funding Information:
This work was supported by the ANR (Agence Nationale de la Recherche), an agency dependent of the French government. Grant: 39SEST2006 - ToxBol. The ANR did not participate in any aspect or stage of the planning, execution, or aftermath of the project.
Publisher Copyright:
© 2015 The Author(s). Published by Taylor & Francis.
PY - 2016/3/3
Y1 - 2016/3/3
N2 - This study assessed lead, arsenic, and antimony in maternal and cord blood, and associations between maternal concentrations and social determinants in the Bolivian mining city of Oruro using the baseline assessment of the ToxBol/Mine-Niño birth cohort. We recruited 467 pregnant women, collecting venous blood and sociodemographic information as well as placental cord blood at birth. Metallic/semimetallic trace elements were measured using inductively coupled plasma mass spectrometry. Lead medians in maternal and cord blood were significantly correlated (Spearman coefficient = 0.59; p < 0.001; 19.35 and 13.50 μg/L, respectively). Arsenic concentrations were above detection limit (3.30 μg/L) in 17.9 % of maternal and 34.6 % of cord blood samples. They were not associated (Fischer's p = 0.72). Antimony medians in maternal and cord blood were weakly correlated (Spearman coefficient = 0.15; p < 0.03; 9.00 and 8.62 μg/L, respectively). Higher concentrations of toxic elements in maternal blood were associated with maternal smoking, low educational level, and partner involved in mining.
AB - This study assessed lead, arsenic, and antimony in maternal and cord blood, and associations between maternal concentrations and social determinants in the Bolivian mining city of Oruro using the baseline assessment of the ToxBol/Mine-Niño birth cohort. We recruited 467 pregnant women, collecting venous blood and sociodemographic information as well as placental cord blood at birth. Metallic/semimetallic trace elements were measured using inductively coupled plasma mass spectrometry. Lead medians in maternal and cord blood were significantly correlated (Spearman coefficient = 0.59; p < 0.001; 19.35 and 13.50 μg/L, respectively). Arsenic concentrations were above detection limit (3.30 μg/L) in 17.9 % of maternal and 34.6 % of cord blood samples. They were not associated (Fischer's p = 0.72). Antimony medians in maternal and cord blood were weakly correlated (Spearman coefficient = 0.15; p < 0.03; 9.00 and 8.62 μg/L, respectively). Higher concentrations of toxic elements in maternal blood were associated with maternal smoking, low educational level, and partner involved in mining.
KW - environmental exposure
KW - maternal exposure
KW - metallic trace elements
KW - prenatal exposure
KW - risk factors
UR - http://www.scopus.com/inward/record.url?scp=84955199306&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/26179629
U2 - 10.1080/09603123.2015.1061114
DO - 10.1080/09603123.2015.1061114
M3 - Article
C2 - 26179629
AN - SCOPUS:84955199306
SN - 0960-3123
VL - 26
SP - 158
EP - 174
JO - International Journal of Environmental Health Research
JF - International Journal of Environmental Health Research
IS - 2
ER -