Towards a 21st-century roadmap for biomedical research and drug discovery: consensus report and recommendations

Gillian R Langley; Ian M Adcock; François Busquet; Kevin M Crofton; Elena Csernok; Christoph Giese; Tuula Heinonen; Kathrin Herrmann; Martin Hofmann-Apitius; Brigitte Landesmann; Lindsay J Marshall; Emily McIvor; Alysson R Muotri; Fozia Noor; Katrin Schutte; Troy Seidle; Anja van de Stolpe; Hilde Van Esch; Catherine Willett; Grzegorz Woszczek

doi:10.1016/j.drudis.2016.10.011

Towards a 21st-century roadmap for biomedical research and drug discovery: consensus report and recommendations

Gillian R Langley, Ian M Adcock, François Busquet, Kevin M Crofton, Elena Csernok, Christoph Giese, Tuula Heinonen, Kathrin Herrmann, Martin Hofmann-Apitius, Brigitte Landesmann, Lindsay J Marshall, Emily McIvor, Alysson R Muotri, Fozia Noor, Katrin Schutte, Troy Seidle, Anja van de Stolpe, Hilde Van Esch, Catherine Willett, Grzegorz Woszczek

Research output: Contribution to journal › Review article › peer-review

63 Citations (Scopus)

Abstract

Decades of costly failures in translating drug candidates from preclinical disease models to human therapeutic use warrant reconsideration of the priority placed on animal models in biomedical research. Following an international workshop attended by experts from academia, government institutions, research funding bodies, and the corporate and non-governmental organisation (NGO) sectors, in this consensus report, we analyse, as case studies, five disease areas with major unmet needs for new treatments. In view of the scientifically driven transition towards a human pathways-based paradigm in toxicology, a similar paradigm shift appears to be justified in biomedical research. There is a pressing need for an approach that strategically implements advanced, human biology-based models and tools to understand disease pathways at multiple biological scales. We present recommendations to help achieve this.

Original language	English
Pages (from-to)	327-339
Number of pages	13
Journal	Drug Discovery Today
Volume	22
Issue number	2
DOIs	https://doi.org/10.1016/j.drudis.2016.10.011
Publication status	Published - Feb 2017
Externally published	Yes

Keywords

Alzheimer Disease
Animals
Asthma
Autism Spectrum Disorder
Autoimmune Diseases
Biomedical Research
Consensus
Cystic Fibrosis
Drug Discovery
Humans
Liver Diseases
Models, Animal

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Langley, G. R., Adcock, I. M., Busquet, F., Crofton, K. M., Csernok, E., Giese, C., Heinonen, T., Herrmann, K., Hofmann-Apitius, M., Landesmann, B., Marshall, L. J., McIvor, E., Muotri, A. R., Noor, F., Schutte, K., Seidle, T., van de Stolpe, A., Van Esch, H., Willett, C., & Woszczek, G. (2017). Towards a 21st-century roadmap for biomedical research and drug discovery: consensus report and recommendations. Drug Discovery Today, 22(2), 327-339. https://doi.org/10.1016/j.drudis.2016.10.011

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abstract = "Decades of costly failures in translating drug candidates from preclinical disease models to human therapeutic use warrant reconsideration of the priority placed on animal models in biomedical research. Following an international workshop attended by experts from academia, government institutions, research funding bodies, and the corporate and non-governmental organisation (NGO) sectors, in this consensus report, we analyse, as case studies, five disease areas with major unmet needs for new treatments. In view of the scientifically driven transition towards a human pathways-based paradigm in toxicology, a similar paradigm shift appears to be justified in biomedical research. There is a pressing need for an approach that strategically implements advanced, human biology-based models and tools to understand disease pathways at multiple biological scales. We present recommendations to help achieve this.",

keywords = "Alzheimer Disease, Animals, Asthma, Autism Spectrum Disorder, Autoimmune Diseases, Biomedical Research, Consensus, Cystic Fibrosis, Drug Discovery, Humans, Liver Diseases, Models, Animal",

author = "Langley, {Gillian R} and Adcock, {Ian M} and Fran{\c c}ois Busquet and Crofton, {Kevin M} and Elena Csernok and Christoph Giese and Tuula Heinonen and Kathrin Herrmann and Martin Hofmann-Apitius and Brigitte Landesmann and Marshall, {Lindsay J} and Emily McIvor and Muotri, {Alysson R} and Fozia Noor and Katrin Schutte and Troy Seidle and {van de Stolpe}, Anja and {Van Esch}, Hilde and Catherine Willett and Grzegorz Woszczek",

year = "2017",

month = feb,

doi = "10.1016/j.drudis.2016.10.011",

language = "English",

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journal = "Drug Discovery Today",

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Langley, GR, Adcock, IM, Busquet, F, Crofton, KM, Csernok, E, Giese, C, Heinonen, T, Herrmann, K, Hofmann-Apitius, M, Landesmann, B, Marshall, LJ, McIvor, E, Muotri, AR, Noor, F, Schutte, K, Seidle, T, van de Stolpe, A, Van Esch, H, Willett, C & Woszczek, G 2017, 'Towards a 21st-century roadmap for biomedical research and drug discovery: consensus report and recommendations', Drug Discovery Today, vol. 22, no. 2, pp. 327-339. https://doi.org/10.1016/j.drudis.2016.10.011

TY - JOUR

T1 - Towards a 21st-century roadmap for biomedical research and drug discovery

T2 - consensus report and recommendations

AU - Langley, Gillian R

AU - Adcock, Ian M

AU - Busquet, François

AU - Crofton, Kevin M

AU - Csernok, Elena

AU - Giese, Christoph

AU - Heinonen, Tuula

AU - Herrmann, Kathrin

AU - Hofmann-Apitius, Martin

AU - Landesmann, Brigitte

AU - Marshall, Lindsay J

AU - McIvor, Emily

AU - Muotri, Alysson R

AU - Noor, Fozia

AU - Schutte, Katrin

AU - Seidle, Troy

AU - van de Stolpe, Anja

AU - Van Esch, Hilde

AU - Willett, Catherine

AU - Woszczek, Grzegorz

PY - 2017/2

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N2 - Decades of costly failures in translating drug candidates from preclinical disease models to human therapeutic use warrant reconsideration of the priority placed on animal models in biomedical research. Following an international workshop attended by experts from academia, government institutions, research funding bodies, and the corporate and non-governmental organisation (NGO) sectors, in this consensus report, we analyse, as case studies, five disease areas with major unmet needs for new treatments. In view of the scientifically driven transition towards a human pathways-based paradigm in toxicology, a similar paradigm shift appears to be justified in biomedical research. There is a pressing need for an approach that strategically implements advanced, human biology-based models and tools to understand disease pathways at multiple biological scales. We present recommendations to help achieve this.

AB - Decades of costly failures in translating drug candidates from preclinical disease models to human therapeutic use warrant reconsideration of the priority placed on animal models in biomedical research. Following an international workshop attended by experts from academia, government institutions, research funding bodies, and the corporate and non-governmental organisation (NGO) sectors, in this consensus report, we analyse, as case studies, five disease areas with major unmet needs for new treatments. In view of the scientifically driven transition towards a human pathways-based paradigm in toxicology, a similar paradigm shift appears to be justified in biomedical research. There is a pressing need for an approach that strategically implements advanced, human biology-based models and tools to understand disease pathways at multiple biological scales. We present recommendations to help achieve this.

KW - Alzheimer Disease

KW - Animals

KW - Asthma

KW - Autism Spectrum Disorder

KW - Autoimmune Diseases

KW - Biomedical Research

KW - Consensus

KW - Cystic Fibrosis

KW - Drug Discovery

KW - Humans

KW - Liver Diseases

KW - Models, Animal

U2 - 10.1016/j.drudis.2016.10.011

DO - 10.1016/j.drudis.2016.10.011

M3 - Review article

C2 - 27989722

SN - 1359-6446

VL - 22

SP - 327

EP - 339

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 2

ER -

Towards a 21st-century roadmap for biomedical research and drug discovery: consensus report and recommendations

Abstract

Keywords

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