TNF and ROS Crosstalk in Inflammation

Heiko Blaser; Catherine Dostert; Tak W. Mak; Dirk Brenner

doi:10.1016/j.tcb.2015.12.002

TNF and ROS Crosstalk in Inflammation

Heiko Blaser, Catherine Dostert, Tak W. Mak, Dirk Brenner^*

^*Corresponding author for this work

Experimental and Molecular Immunology

Research output: Contribution to journal › Review article › peer-review

812 Citations (Scopus)

Abstract

Tumor necrosis factor (TNF) is tremendously important for mammalian immunity and cellular homeostasis. The role of TNF as a master regulator in balancing cell survival, apoptosis and necroptosis has been extensively studied in various cell types and tissues. Although these findings have revealed much about the direct impact of TNF on the regulation of NF-κB and JNK, there is now rising interest in understanding the emerging function of TNF as a regulator of the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). In this review we summarize work aimed at defining the role of TNF in the control of ROS/RNS signaling that influences innate immune cells under both physiological and inflammatory conditions.

Original language	English
Pages (from-to)	249-261
Number of pages	13
Journal	Trends in Cell Biology
Volume	26
Issue number	4
DOIs	https://doi.org/10.1016/j.tcb.2015.12.002
Publication status	Published - 2016

Keywords

Immunity
Inflammation
NADPH oxidase (NOX)
Necroptosis
Reactive oxygen species (ROS)
Tumor necrosis factor (TNF)

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10.1016/j.tcb.2015.12.002

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title = "TNF and ROS Crosstalk in Inflammation",

abstract = "Tumor necrosis factor (TNF) is tremendously important for mammalian immunity and cellular homeostasis. The role of TNF as a master regulator in balancing cell survival, apoptosis and necroptosis has been extensively studied in various cell types and tissues. Although these findings have revealed much about the direct impact of TNF on the regulation of NF-κB and JNK, there is now rising interest in understanding the emerging function of TNF as a regulator of the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). In this review we summarize work aimed at defining the role of TNF in the control of ROS/RNS signaling that influences innate immune cells under both physiological and inflammatory conditions.",

keywords = "Immunity, Inflammation, NADPH oxidase (NOX), Necroptosis, Reactive oxygen species (ROS), Tumor necrosis factor (TNF)",

author = "Heiko Blaser and Catherine Dostert and Mak, {Tak W.} and Dirk Brenner",

note = "Funding Information: The authors thank M. Saunders for excellent scientific editing, K. Weger for the contribution of the glossary and research assistance, and M. Brenner for general support. H.B. is funded by a Canadian Institutes of Health Research (CIHR) S2B award (141816), and D.B. is funded by the ATTRACT Programme and a CORE grant (C15/BM/10355103) of the National Research Fund Luxembourg (FNR). Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2016",

doi = "10.1016/j.tcb.2015.12.002",

language = "English",

volume = "26",

pages = "249--261",

journal = "Trends in Cell Biology",

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TY - JOUR

T1 - TNF and ROS Crosstalk in Inflammation

AU - Blaser, Heiko

AU - Dostert, Catherine

AU - Mak, Tak W.

AU - Brenner, Dirk

N1 - Funding Information: The authors thank M. Saunders for excellent scientific editing, K. Weger for the contribution of the glossary and research assistance, and M. Brenner for general support. H.B. is funded by a Canadian Institutes of Health Research (CIHR) S2B award (141816), and D.B. is funded by the ATTRACT Programme and a CORE grant (C15/BM/10355103) of the National Research Fund Luxembourg (FNR). Publisher Copyright: © 2015 Elsevier Ltd.

PY - 2016

Y1 - 2016

N2 - Tumor necrosis factor (TNF) is tremendously important for mammalian immunity and cellular homeostasis. The role of TNF as a master regulator in balancing cell survival, apoptosis and necroptosis has been extensively studied in various cell types and tissues. Although these findings have revealed much about the direct impact of TNF on the regulation of NF-κB and JNK, there is now rising interest in understanding the emerging function of TNF as a regulator of the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). In this review we summarize work aimed at defining the role of TNF in the control of ROS/RNS signaling that influences innate immune cells under both physiological and inflammatory conditions.

AB - Tumor necrosis factor (TNF) is tremendously important for mammalian immunity and cellular homeostasis. The role of TNF as a master regulator in balancing cell survival, apoptosis and necroptosis has been extensively studied in various cell types and tissues. Although these findings have revealed much about the direct impact of TNF on the regulation of NF-κB and JNK, there is now rising interest in understanding the emerging function of TNF as a regulator of the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). In this review we summarize work aimed at defining the role of TNF in the control of ROS/RNS signaling that influences innate immune cells under both physiological and inflammatory conditions.

KW - Immunity

KW - Inflammation

KW - NADPH oxidase (NOX)

KW - Necroptosis

KW - Reactive oxygen species (ROS)

KW - Tumor necrosis factor (TNF)

UR - http://www.scopus.com/inward/record.url?scp=84954285142&partnerID=8YFLogxK

UR - https://pubmed.ncbi.nlm.nih.gov/26791157

U2 - 10.1016/j.tcb.2015.12.002

DO - 10.1016/j.tcb.2015.12.002

M3 - Review article

C2 - 26791157

AN - SCOPUS:84954285142

SN - 0962-8924

VL - 26

SP - 249

EP - 261

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 4

ER -

TNF and ROS Crosstalk in Inflammation

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Keywords

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