TNF and ROS Crosstalk in Inflammation

Heiko Blaser, Catherine Dostert, Tak W. Mak, Dirk Brenner*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

510 Citations (Scopus)

Abstract

Tumor necrosis factor (TNF) is tremendously important for mammalian immunity and cellular homeostasis. The role of TNF as a master regulator in balancing cell survival, apoptosis and necroptosis has been extensively studied in various cell types and tissues. Although these findings have revealed much about the direct impact of TNF on the regulation of NF-κB and JNK, there is now rising interest in understanding the emerging function of TNF as a regulator of the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). In this review we summarize work aimed at defining the role of TNF in the control of ROS/RNS signaling that influences innate immune cells under both physiological and inflammatory conditions.

Original languageEnglish
Pages (from-to)249-261
Number of pages13
JournalTrends in Cell Biology
Volume26
Issue number4
DOIs
Publication statusPublished - 2016

Keywords

  • Immunity
  • Inflammation
  • NADPH oxidase (NOX)
  • Necroptosis
  • Reactive oxygen species (ROS)
  • Tumor necrosis factor (TNF)

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