TY - JOUR
T1 - Time interval between surgery and start of adjuvant radiotherapy in patients with soft tissue sarcoma
T2 - A retrospective analysis of 1131 cases from the French Sarcoma Group
AU - Fourquet, Jacques
AU - Sunyach, Marie Pierre
AU - Vilotte, Florent
AU - Le Péchoux, Cécile
AU - Ranchère-Vince, Dominique
AU - Bonvalot, Sylvie
AU - Coindre, Jean Michel
AU - Terrier, Philippe
AU - Meeus, Pierre
AU - Helfre, Sylvie
AU - Martin, Etienne
AU - Vogin, Guillaume
AU - Biau, Julian
AU - Kao, William
AU - Noel, Georges
AU - Ducassou, Anne
AU - Llacer-Moscardo, Carmen
AU - Stoeckle, Eberhard
AU - Penel, Nicolas
AU - Sargos, Paul
N1 - Publisher Copyright:
© 2016 Elsevier Ireland Ltd
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Purpose The aim of this study was to evaluate the impact of the time interval (TI) between surgery and adjuvant radiotherapy (RT) in soft tissue sarcoma (STS). Methods and materials Data from 1131 patients treated between 1990 and 2014 were retrospectively reviewed. Inclusion criteria were: limb or superficial trunk wall STS (R0 or R1 resection) and adjuvant RT. The impact of TI on 10-year local relapse-free survival (LRFS) and 10-year overall survival (OS) was analyzed using a Log-rank test and then Cox Model. Results The median TI was 82 days (range, 18–346). With a median follow-up of 235 months (range, 2–296 months), the 10-year LRFS was 57.5% (±2%) and the 10-year OS was 64.2% (±2%). With a TI of 19–39 days, 40–79 days, 80–119 days, and ⩾120 days, 10-year LRFSs were 65.3%, 55.5%, 56.9% and 61.2% (p = 0.465), and 10-year OSs were 72.8%, 60.7%, 66.4% and 62.1% (p = 0.347), respectively. After adjustment for the factors significantly (p ⩽ 0.05) associated with LRFS and OS, TI did not alter LRFS (p = 0.182) either OS (p = 0.335). Conclusions In this retrospective STS database study, the TI between surgery and start of adjuvant RT did not seem to affect outcomes.
AB - Purpose The aim of this study was to evaluate the impact of the time interval (TI) between surgery and adjuvant radiotherapy (RT) in soft tissue sarcoma (STS). Methods and materials Data from 1131 patients treated between 1990 and 2014 were retrospectively reviewed. Inclusion criteria were: limb or superficial trunk wall STS (R0 or R1 resection) and adjuvant RT. The impact of TI on 10-year local relapse-free survival (LRFS) and 10-year overall survival (OS) was analyzed using a Log-rank test and then Cox Model. Results The median TI was 82 days (range, 18–346). With a median follow-up of 235 months (range, 2–296 months), the 10-year LRFS was 57.5% (±2%) and the 10-year OS was 64.2% (±2%). With a TI of 19–39 days, 40–79 days, 80–119 days, and ⩾120 days, 10-year LRFSs were 65.3%, 55.5%, 56.9% and 61.2% (p = 0.465), and 10-year OSs were 72.8%, 60.7%, 66.4% and 62.1% (p = 0.347), respectively. After adjustment for the factors significantly (p ⩽ 0.05) associated with LRFS and OS, TI did not alter LRFS (p = 0.182) either OS (p = 0.335). Conclusions In this retrospective STS database study, the TI between surgery and start of adjuvant RT did not seem to affect outcomes.
KW - Postoperative radiotherapy
KW - Soft tissue sarcoma
KW - Time interval
UR - http://www.scopus.com/inward/record.url?scp=84971299932&partnerID=8YFLogxK
U2 - 10.1016/j.radonc.2016.04.037
DO - 10.1016/j.radonc.2016.04.037
M3 - Article
C2 - 27207359
AN - SCOPUS:84971299932
SN - 0167-8140
VL - 120
SP - 156
EP - 162
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
IS - 1
ER -