Therapeutic control and resistance of the EGFR-driven signaling network in glioblastoma

Francisco Azuaje*, Katja Tiemann, Simone P. Niclou

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)

Abstract

The alteration of the epidermal growth factor receptor (EGFR)-driven signaling network is a characteristic feature of glioblastomas (GBM), and its inhibition represents a treatment strategy. However, EGFR-targeted interventions have been largely ineffective. Complex perturbations in this system are likely to be central to tumor cells with high adaptive capacity and resistance to therapies. We review key concepts and mechanisms relevant to EGFR-targeted treatment resistance at a systems level. Our understanding of treatment resistance as a systems-level phenomenon is necessary to develop effective therapeutic options for GBM patients. This is allowing us to go beyond the notion of therapeutic targets as single molecular components, into strategies that can weaken cancer signaling robustness and boost inherent network-level vulnerabilities.

Original languageEnglish
Article number23
JournalCell Communication and Signaling
Volume13
Issue number1
DOIs
Publication statusPublished - 31 Mar 2015

Keywords

  • Epidermal growth factor receptor (EGFR)
  • Glioblastoma
  • Resistance to treatment
  • Systems biology
  • Targeted therapies

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