TY - JOUR
T1 - The role of heparan sulfate maturation in cancer
T2 - A focus on the 3O-sulfation and the enigmatic 3O-sulfotransferases (HS3STs)
AU - Gulberti, Sandrine
AU - Mao, Xianqing
AU - Bui, Catherine
AU - Fournel-Gigleux, Sylvie
N1 - Funding Information:
The authors would like to apologize to colleagues that although recognized experts in the field could not quoted. The GDR GAGosciences , Ligue contre le cancer , CPER , Région Grand-Est, are acknowledged for funding the research work of the MolcelTEG team and Glyco-Psi Platform. Ciara Gigleux is acknowledged for expert editing. Dr. Nick Ramalanjaona is greatly acknowledged for is valuable contribution, and Isabelle Bertin-Jung and Anne Robert for expert technical support.
Funding Information:
The authors would like to apologize to colleagues that although recognized experts in the field could not quoted. The GDR GAGosciences, Ligue contre le cancer, CPER, R?gion Grand-Est, are acknowledged for funding the research work of the MolcelTEG team and Glyco-Psi Platform. Ciara Gigleux is acknowledged for expert editing. Dr. Nick Ramalanjaona is greatly acknowledged for is valuable contribution, and Isabelle Bertin-Jung and Anne Robert for expert technical support.
Publisher Copyright:
© 2019
PY - 2020/5
Y1 - 2020/5
N2 - Heparansulfate (HS) modifications are master regulators of the cross-talk between cell and matrix and modulate the biological activity of an array of HS binding proteins, including growth factors and chemokines, morphogens and immunity cell receptors. This review will highlight the importance of HS maturation mediated by N-deactetylase/sulfotransferases, 2O- and 6O-sulfotransferases in cancer biology, and will focus on the 3O-sulfotransferases and on the terminal, rare 3O-sulfation, and their important but still enigmatic impact in cancer progression. The review will also discuss the molecular mechanisms of action of these HS modifications with regards to ligand interactions and signaling in the cancer process and their clinical significance.
AB - Heparansulfate (HS) modifications are master regulators of the cross-talk between cell and matrix and modulate the biological activity of an array of HS binding proteins, including growth factors and chemokines, morphogens and immunity cell receptors. This review will highlight the importance of HS maturation mediated by N-deactetylase/sulfotransferases, 2O- and 6O-sulfotransferases in cancer biology, and will focus on the 3O-sulfotransferases and on the terminal, rare 3O-sulfation, and their important but still enigmatic impact in cancer progression. The review will also discuss the molecular mechanisms of action of these HS modifications with regards to ligand interactions and signaling in the cancer process and their clinical significance.
KW - 3O-sulfation
KW - Cancer
KW - Heparan sulfate
KW - Heparan sulfate binding proteins
KW - Sulfotransferases
UR - http://www.scopus.com/inward/record.url?scp=85075376041&partnerID=8YFLogxK
U2 - 10.1016/j.semcancer.2019.10.009
DO - 10.1016/j.semcancer.2019.10.009
M3 - Review article
C2 - 31711992
AN - SCOPUS:85075376041
SN - 1044-579X
VL - 62
SP - 68
EP - 85
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
ER -