@article{3164991755684a16b819515f4d742c05,
title = "The role of epigenetics in cardiovascular health and ageing: A focus on physical activity and nutrition",
abstract = "The cardiovascular system is responsible for transport of blood and nutrients to tissues, and is pivotal to the physiological health and longevity. Epigenetic modification is a natural, age-associated process resulting in highly contextualised gene expression with clear implications for cell differentiation and disease onset. Biological/epigenetic age is independent of chronological age, constituting a highly reflective snapshot of an individual's overall health. Accelerated vascular ageing is of major concern, effectively lowering disease threshold. Age-related chronic illness involves a complex interplay between many biological processes and is modulated by non-modifiable and modifiable risk factors. These alter the static genome by a number of epigenetic mechanisms, which change gene expression in an age and lifestyle dependent manner. This {\textquoteleft}epigenetic drift{\textquoteright} impacts health and contributes to the etiology of chronic illness. Lifestyle factors may cause acceleration of this epigenetic “clock” pre-disposing individuals to cardiovascular disease. Nutrition and physical activity are modifiable lifestyle choices, synergistically contributing to cardiovascular health. They represent a powerful potential epigenetic intervention point for effective cardiovascular protective and management strategies. Thus, together with traditional risk factors, monitoring the epigenetic signature of ageing may prove beneficial for tailoring lifestyle to fit biology – supporting the increasingly popular concept of “ageing well”.",
keywords = "Ageing, Cardiovascular disease, Epigenetics, Exercise, Nutrition",
author = "Wallace, {Robert G.} and Twomey, {Laura C.} and Custaud, {Marc Antoine} and Turner, {Jonathan D.} and Niall Moyna and Cummins, {Philip M.} and Murphy, {Ronan P.}",
note = "Funding Information: The authors acknowledge financial support provided through the Irish Higher Education Authority Programme for Research in Third Level Institutes (HEA-PRTLI Cycle 4: T3 Targeted Therapeutics & Theranostics), Health Research Board of Ireland ( HRB- RP/2005/184 , HRA/2009/122 , HRA/2009/122/R ), Science Foundation Ireland ( SFI- 04/BR/B0577 , 11/TIDA/B1927 ), Irish Research Council ( RS/2011/695 , RS/2012/2499 ) and Enterprise Ireland ( EI- PC/2009/0311 , IP 2015 0399Y , IP 2015 0418 , IP 2017 0587 ) to RPM. JDT is supported by grants from the Fonds Nationale de Recherche, Luxembourg ( C12/BM/3985792 “EpiPath”, and C16/BM/11342695 “MetCOEPs”), and the Luxembourg Personalised Medicine Consortium ( PMC/2016/05 “ESPoiRe”). Dr.{\textquoteright}s Ronan Murphy and Jonathan Turner are management committee members of the EU H2020 funded COST action- CM1406, EpiChemBio. Prof. M.A Custaud{\textquoteright}s work was supported by the Centre national d'{\'e}tudes spatiales (CNES) (CNES grant number 2015 48 0000079 ). Funding Information: The authors acknowledge financial support provided through the Irish Higher Education Authority Programme for Research in Third Level Institutes (HEA-PRTLI Cycle 4: T3 Targeted Therapeutics & Theranostics), Health Research Board of Ireland (HRB- RP/2005/184, HRA/2009/122, HRA/2009/122/R), Science Foundation Ireland (SFI- 04/BR/B0577, 11/TIDA/B1927), Irish Research Council (RS/2011/695, RS/2012/2499) and Enterprise Ireland (EI- PC/2009/0311, IP 2015 0399Y, IP 2015 0418, IP 2017 0587) to RPM. JDT is supported by grants from the Fonds Nationale de Recherche, Luxembourg (C12/BM/3985792 ?EpiPath? and C16/BM/11342695 ?MetCOEPs?), and the Luxembourg Personalised Medicine Consortium (PMC/2016/05 ?ESPoiRe?). Dr.?s Ronan Murphy and Jonathan Turner are management committee members of the EU H2020 funded COST action- CM1406, EpiChemBio. Prof. M.A Custaud's work was supported by the Centre national d'?tudes spatiales (CNES) (CNES grant number 2015 48 0000079). Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",
year = "2018",
month = sep,
doi = "10.1016/j.mad.2017.11.013",
language = "English",
volume = "174",
pages = "76--85",
journal = "Mechanisms of Ageing and Development",
issn = "0047-6374",
publisher = "Elsevier Ireland Ltd",
}