The role of DNA methylation: linking exposure to phenotype

Fleur Leenen

The role of DNA methylation: linking exposure to phenotype

Fleur Leenen

Immune Endocrine and Epigenetics

Research output: Types of Thesis › Doctoral Thesis

Abstract

DNA methylation, through 5-methyl- and 5-hydroxymethylcytosine (5mC and 5hmC) is considered to be one of the principal interfaces between the genome and our environment and it helps explain phenotypic variations in human populations. Initial reports of large differences in methylation level in genomic regulatory regions, coupled with clear gene expression data in both imprinted genes and malignant diseases provided easily dissected molecular mechanisms for switching genes on or off. However, a more subtle process is becoming evident, where small (

Original language	English
Awarding Institution	Trier University
Supervisors/Advisors	Turner, Jonathan, Supervisor
Award date	11 Aug 2017
Publisher	University of Trier
Publication status	Published - 11 Aug 2017

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title = "The role of DNA methylation: linking exposure to phenotype",

abstract = "DNA methylation, through 5-methyl- and 5-hydroxymethylcytosine (5mC and 5hmC) is considered to be one of the principal interfaces between the genome and our environment and it helps explain phenotypic variations in human populations. Initial reports of large differences in methylation level in genomic regulatory regions, coupled with clear gene expression data in both imprinted genes and malignant diseases provided easily dissected molecular mechanisms for switching genes on or off. However, a more subtle process is becoming evident, where small (",

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AU - Leenen, Fleur

PY - 2017/8/11

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N2 - DNA methylation, through 5-methyl- and 5-hydroxymethylcytosine (5mC and 5hmC) is considered to be one of the principal interfaces between the genome and our environment and it helps explain phenotypic variations in human populations. Initial reports of large differences in methylation level in genomic regulatory regions, coupled with clear gene expression data in both imprinted genes and malignant diseases provided easily dissected molecular mechanisms for switching genes on or off. However, a more subtle process is becoming evident, where small (

AB - DNA methylation, through 5-methyl- and 5-hydroxymethylcytosine (5mC and 5hmC) is considered to be one of the principal interfaces between the genome and our environment and it helps explain phenotypic variations in human populations. Initial reports of large differences in methylation level in genomic regulatory regions, coupled with clear gene expression data in both imprinted genes and malignant diseases provided easily dissected molecular mechanisms for switching genes on or off. However, a more subtle process is becoming evident, where small (

M3 - Doctoral Thesis

PB - University of Trier

ER -

The role of DNA methylation: linking exposure to phenotype

Abstract

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