The role of DNA methylation: linking exposure to phenotype

Fleur Leenen

Research output: Types of ThesisDoctoral Thesis


DNA methylation, through 5-methyl- and 5-hydroxymethylcytosine (5mC and 5hmC) is considered to be one of the principal interfaces between the genome and our environment and it helps explain phenotypic variations in human populations. Initial reports of large differences in methylation level in genomic regulatory regions, coupled with clear gene expression data in both imprinted genes and malignant diseases provided easily dissected molecular mechanisms for switching genes on or off. However, a more subtle process is becoming evident, where small (
Original languageEnglish
Awarding Institution
  • Trier University
  • Turner, Jonathan, Supervisor
Award date11 Aug 2017
Publication statusPublished - 11 Aug 2017


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