The role of dj-1 in cellular metabolism and pathophysiological implications for parkinson’s disease

Pauline Mencke; Ibrahim Boussaad; Chiara D. Romano; Toshimori Kitami; Carole L. Linster; Rejko Krüger

doi:10.3390/cells10020347

The role of dj-1 in cellular metabolism and pathophysiological implications for parkinson’s disease

Pauline Mencke^*
, Ibrahim Boussaad
, Chiara D. Romano
, Toshimori Kitami
, Carole L. Linster
, Rejko Krüger

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

48 Citations (Scopus)

Abstract

DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different chronic diseases including neurodegeneration, cancer and diabetes. Several of the physiological functions of DJ-1 are not yet fully understood; however, in the last years, there has been increasing evidence for a potential role of DJ-1 in the regulation of cellular metabolism. Here, we summarize the current knowledge on specific functions of DJ-1 relevant to cellular metabolism and their role in modulating metabolic pathways. Further, we illustrate pathophysiological implications of the metabolic effects of DJ-1 in the context of neurodegeneration in Parkinson´s disease.

Original language	English
Article number	347
Pages (from-to)	1-17
Number of pages	17
Journal	Cells
Volume	10
Issue number	2
DOIs	https://doi.org/10.3390/cells10020347
Publication status	Published - 7 Feb 2021

Keywords

DJ-1
Metabolism
Parkinson´s disease

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10.3390/cells10020347Licence: CC BY

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title = "The role of dj-1 in cellular metabolism and pathophysiological implications for parkinson{\textquoteright}s disease",

abstract = "DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different chronic diseases including neurodegeneration, cancer and diabetes. Several of the physiological functions of DJ-1 are not yet fully understood; however, in the last years, there has been increasing evidence for a potential role of DJ-1 in the regulation of cellular metabolism. Here, we summarize the current knowledge on specific functions of DJ-1 relevant to cellular metabolism and their role in modulating metabolic pathways. Further, we illustrate pathophysiological implications of the metabolic effects of DJ-1 in the context of neurodegeneration in Parkinson´s disease.",

keywords = "DJ-1, Metabolism, Parkinson´s disease",

author = "Pauline Mencke and Ibrahim Boussaad and Romano, \{Chiara D.\} and Toshimori Kitami and Linster, \{Carole L.\} and Rejko Kr{\"u}ger",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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TY - JOUR

T1 - The role of dj-1 in cellular metabolism and pathophysiological implications for parkinson’s disease

AU - Mencke, Pauline

AU - Boussaad, Ibrahim

AU - Romano, Chiara D.

AU - Kitami, Toshimori

AU - Linster, Carole L.

AU - Krüger, Rejko

PY - 2021/2/7

Y1 - 2021/2/7

N2 - DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different chronic diseases including neurodegeneration, cancer and diabetes. Several of the physiological functions of DJ-1 are not yet fully understood; however, in the last years, there has been increasing evidence for a potential role of DJ-1 in the regulation of cellular metabolism. Here, we summarize the current knowledge on specific functions of DJ-1 relevant to cellular metabolism and their role in modulating metabolic pathways. Further, we illustrate pathophysiological implications of the metabolic effects of DJ-1 in the context of neurodegeneration in Parkinson´s disease.

AB - DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different chronic diseases including neurodegeneration, cancer and diabetes. Several of the physiological functions of DJ-1 are not yet fully understood; however, in the last years, there has been increasing evidence for a potential role of DJ-1 in the regulation of cellular metabolism. Here, we summarize the current knowledge on specific functions of DJ-1 relevant to cellular metabolism and their role in modulating metabolic pathways. Further, we illustrate pathophysiological implications of the metabolic effects of DJ-1 in the context of neurodegeneration in Parkinson´s disease.

KW - DJ-1

KW - Metabolism

KW - Parkinson´s disease

UR - https://www.scopus.com/pages/publications/85101016539

UR - https://www.ncbi.nlm.nih.gov/pubmed/33562311

U2 - 10.3390/cells10020347

DO - 10.3390/cells10020347

M3 - Review article

C2 - 33562311

AN - SCOPUS:85101016539

SN - 2073-4409

VL - 10

SP - 1

EP - 17

JO - Cells

JF - Cells

IS - 2

M1 - 347

ER -

The role of dj-1 in cellular metabolism and pathophysiological implications for parkinson’s disease

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