The role of dj-1 in cellular metabolism and pathophysiological implications for parkinson’s disease

Pauline Mencke*, Ibrahim Boussaad, Chiara D. Romano, Toshimori Kitami, Carole L. Linster, Rejko Krüger

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)

Abstract

DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different chronic diseases including neurodegeneration, cancer and diabetes. Several of the physiological functions of DJ-1 are not yet fully understood; however, in the last years, there has been increasing evidence for a potential role of DJ-1 in the regulation of cellular metabolism. Here, we summarize the current knowledge on specific functions of DJ-1 relevant to cellular metabolism and their role in modulating metabolic pathways. Further, we illustrate pathophysiological implications of the metabolic effects of DJ-1 in the context of neurodegeneration in Parkinson´s disease.

Original languageEnglish
Article number347
Pages (from-to)1-17
Number of pages17
JournalCells
Volume10
Issue number2
DOIs
Publication statusPublished - 7 Feb 2021

Keywords

  • DJ-1
  • Metabolism
  • Parkinson´s disease

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