The role of dj-1 in cellular metabolism and pathophysiological implications for parkinson’s disease

Pauline Mencke; Ibrahim Boussaad; Chiara D. Romano; Toshimori Kitami; Carole L. Linster; Rejko Krüger

doi:10.3390/cells10020347

The role of dj-1 in cellular metabolism and pathophysiological implications for parkinson’s disease

Pauline Mencke^*, Ibrahim Boussaad, Chiara D. Romano, Toshimori Kitami, Carole L. Linster, Rejko Krüger

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

35 Citations (Scopus)

Abstract

DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different chronic diseases including neurodegeneration, cancer and diabetes. Several of the physiological functions of DJ-1 are not yet fully understood; however, in the last years, there has been increasing evidence for a potential role of DJ-1 in the regulation of cellular metabolism. Here, we summarize the current knowledge on specific functions of DJ-1 relevant to cellular metabolism and their role in modulating metabolic pathways. Further, we illustrate pathophysiological implications of the metabolic effects of DJ-1 in the context of neurodegeneration in Parkinson´s disease.

Original language	English
Article number	347
Pages (from-to)	1-17
Number of pages	17
Journal	Cells
Volume	10
Issue number	2
DOIs	https://doi.org/10.3390/cells10020347
Publication status	Published - 7 Feb 2021

Keywords

DJ-1
Metabolism
Parkinson´s disease

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10.3390/cells10020347Licence: CC BY

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title = "The role of dj-1 in cellular metabolism and pathophysiological implications for parkinson{\textquoteright}s disease",

abstract = "DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different chronic diseases including neurodegeneration, cancer and diabetes. Several of the physiological functions of DJ-1 are not yet fully understood; however, in the last years, there has been increasing evidence for a potential role of DJ-1 in the regulation of cellular metabolism. Here, we summarize the current knowledge on specific functions of DJ-1 relevant to cellular metabolism and their role in modulating metabolic pathways. Further, we illustrate pathophysiological implications of the metabolic effects of DJ-1 in the context of neurodegeneration in Parkinson´s disease.",

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AU - Mencke, Pauline

AU - Boussaad, Ibrahim

AU - Romano, Chiara D.

AU - Kitami, Toshimori

AU - Linster, Carole L.

AU - Krüger, Rejko

PY - 2021/2/7

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N2 - DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different chronic diseases including neurodegeneration, cancer and diabetes. Several of the physiological functions of DJ-1 are not yet fully understood; however, in the last years, there has been increasing evidence for a potential role of DJ-1 in the regulation of cellular metabolism. Here, we summarize the current knowledge on specific functions of DJ-1 relevant to cellular metabolism and their role in modulating metabolic pathways. Further, we illustrate pathophysiological implications of the metabolic effects of DJ-1 in the context of neurodegeneration in Parkinson´s disease.

AB - DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different chronic diseases including neurodegeneration, cancer and diabetes. Several of the physiological functions of DJ-1 are not yet fully understood; however, in the last years, there has been increasing evidence for a potential role of DJ-1 in the regulation of cellular metabolism. Here, we summarize the current knowledge on specific functions of DJ-1 relevant to cellular metabolism and their role in modulating metabolic pathways. Further, we illustrate pathophysiological implications of the metabolic effects of DJ-1 in the context of neurodegeneration in Parkinson´s disease.

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KW - Metabolism

KW - Parkinson´s disease

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The role of dj-1 in cellular metabolism and pathophysiological implications for parkinson’s disease

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