The role of α-synuclein gene multiplications in early-onset Parkinson's disease and dementia with Lewy bodies

A. Hofer, D. Berg, F. Asmus, M. Niwar, G. Ransmayr, M. Riemenschneider, S. B. Bonelli, M. Steffelbauer, A. Ceballos-Baumann, P. Haussermann, S. Behnke, R. Krüger, J. Prestel, M. Sharma, A. Zimprich, O. Riess, T. Gasser*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Abstract

Background: A triplication of the α-synuclein gene was found to cause autosomal dominant Lewy body disease in two distinct families. Method: We searched for alterations of α-synuclein gene dosage and analysed the entire coding region for point mutations in 54 dementia with Lewy body disease (DLB) and in 103 young onset Parkinson's disease (PD) patients from Central Europe. Results: We could not detect any quantitative alterations in the gene dosage of α-synuclein. Mutational screening of the entire coding region of α-synuclein revealed only one silent mutation V3V (adenine9guanine) in one case. Conclusions: Thus, this phenomenon appears not to be a major cause in the pathogenesis of sporadic DLB and young onset PD in this European population.

Original languageEnglish
Pages (from-to)1249-1254
Number of pages6
JournalJournal of Neural Transmission
Volume112
Issue number9
DOIs
Publication statusPublished - Sep 2005
Externally publishedYes

Keywords

  • Alpha-synuclein
  • Lewy-body
  • Parkinson's disease

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