TY - JOUR
T1 - The risk of infertility and dietary inflammatory index, a case–control study in Iran
AU - KabodMehri, Roya
AU - Vahid, Farhad
AU - Nami, Sheyda
AU - Ghadimi, Hadis
AU - Dorosti, Masoumeh
AU - Tejareh, Faezeh
AU - Shamsi-Goushki, Ali
AU - Bahmani, Parsa
AU - Karimi, Hoora
AU - Ajami, Marjan
AU - Doaei, Saeid
AU - Gholamalizadeh, Maryam
N1 - Funding:
Funding for this study was provided by Guilan University of Medical Sciences, Rasht, Iran (Code 4047).
Publisher Copyright:
© The Author(s) 2025.
PY - 2025/10/29
Y1 - 2025/10/29
N2 - Background: Infertility is defined as the inability to conceive after 12 months of unprotected sexual intercourse and affects 15% of couples globally. Diet influences inflammatory factors, potentially affecting ovarian reserve and thus may have a role in infertility. The present study aimed to assess the association between infertility and the Dietary Inflammatory Index (DII). Methods: This case–control study was conducted at Al-Zahra Hospital, Rasht, Iran, on 123 infertile women and 123 healthy participants. Food intake was assessed using a validated FFQ. The DII was calculated, and logistic regression analysis was performed to assess the relationship between DII and ovarian reserve. Results: Individuals with a higher DII had a greater risk of infertility compared to those with a lower DII (OR = 2.08, CI 95% = 1.024–4.248, P = 0.043) after adjustment for age, weight, body mass index, intake of anti-inflammatory supplements, suffering from underlying disease, smoking, alcohol consumption, and physical activity. Further adjustments for infertility duration, thyroid disorders, FSH, LH, and number of fertilities did not change the results. Conclusion: The dietary inflammatory index (DII) was positively associated with infertility. A higher inflammatory diet may increase the likelihood of infertility. Further research is needed to fully understand this connection.
AB - Background: Infertility is defined as the inability to conceive after 12 months of unprotected sexual intercourse and affects 15% of couples globally. Diet influences inflammatory factors, potentially affecting ovarian reserve and thus may have a role in infertility. The present study aimed to assess the association between infertility and the Dietary Inflammatory Index (DII). Methods: This case–control study was conducted at Al-Zahra Hospital, Rasht, Iran, on 123 infertile women and 123 healthy participants. Food intake was assessed using a validated FFQ. The DII was calculated, and logistic regression analysis was performed to assess the relationship between DII and ovarian reserve. Results: Individuals with a higher DII had a greater risk of infertility compared to those with a lower DII (OR = 2.08, CI 95% = 1.024–4.248, P = 0.043) after adjustment for age, weight, body mass index, intake of anti-inflammatory supplements, suffering from underlying disease, smoking, alcohol consumption, and physical activity. Further adjustments for infertility duration, thyroid disorders, FSH, LH, and number of fertilities did not change the results. Conclusion: The dietary inflammatory index (DII) was positively associated with infertility. A higher inflammatory diet may increase the likelihood of infertility. Further research is needed to fully understand this connection.
KW - DII
KW - Diet
KW - Dietary inflammatory index
KW - Infertility
UR - https://www.scopus.com/pages/publications/105020043833
UR - https://pubmed.ncbi.nlm.nih.gov/41162666/
U2 - 10.1007/s00404-025-08222-0
DO - 10.1007/s00404-025-08222-0
M3 - Article
C2 - 41162666
AN - SCOPUS:105020043833
SN - 0932-0067
JO - Archives of Gynecology and Obstetrics
JF - Archives of Gynecology and Obstetrics
ER -