The rise of mitochondria in peripheral arterial disease physiopathology: Experimental and clinical data

Mégane Pizzimenti, Marianne Riou, Anne Laure Charles, Samy Talha, Alain Meyer, Emmanuel Andres, Nabil Chakfé, Anne Lejay, Bernard Geny*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

26 Citations (Scopus)

Abstract

Peripheral arterial disease (PAD) is a frequent and serious condition, potentially life-threatening and leading to lower-limb amputation. Its pathophysiology is generally related to ischemia-reperfusion cycles, secondary to reduction or interruption of the arterial blood flow followed by reperfusion episodes that are necessary but also—per se—deleterious. Skeletal muscles alterations significantly participate in PAD injuries, and interestingly, muscle mitochondrial dysfunctions have been demonstrated to be key events and to have a prognosis value. Decreased oxidative capacity due to mitochondrial respiratory chain impairment is associated with increased release of reactive oxygen species and reduction of calcium retention capacity leading thus to enhanced apoptosis. Therefore, targeting mitochondria might be a promising therapeutic approach in PAD.

Original languageEnglish
Article number2125
JournalJournal of Clinical Medicine
Volume8
Issue number12
DOIs
Publication statusPublished - Dec 2019
Externally publishedYes

Keywords

  • Antioxidant
  • Apoptosis
  • Calcium retention capacity
  • Ischemia-reperfusion
  • Mitochondria
  • Oxidative stress
  • Peripheral arterial disease
  • Reactive oxygen species

Fingerprint

Dive into the research topics of 'The rise of mitochondria in peripheral arterial disease physiopathology: Experimental and clinical data'. Together they form a unique fingerprint.

Cite this