TY - JOUR
T1 - The prevalence of physical multimorbidity among people with non-affective psychotic disorders 10 years after first diagnosis
T2 - a matched retrospective cohort study
AU - Rodrigues, Myanca
AU - Stranges, Saverio
AU - Ryan, Bridget L.
AU - Anderson, Kelly K.
N1 - Funding Information:
This work was supported by a grant from the Canadian Institutes for Health Research (#153022), an Early Researcher Award from the Ontario Ministry of Research, Innovation, and Science (KKA), and the Dr. Carol Buck Graduate Scholarship in Epidemiology from the Department of Epidemiology and Biostatistics at Western University (MR).
Publisher Copyright:
© 2021, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2022/3
Y1 - 2022/3
N2 - Aims: The higher prevalence of chronic physical health conditions among people with psychotic disorders may result in a reduced life expectancy as compared to the general population. More research is needed on the risk of multiple co-occurring chronic health conditions, known as multimorbidity, for people with psychotic disorders. Methods: We conducted a matched retrospective cohort study to quantify the prevalence of multimorbidity and associated factors among people with psychotic disorders over the 10-year period following first diagnosis, relative to those without psychosis. Data from an early psychosis intervention program in London, Canada were linked to population-based health administrative data to identify patients with first-episode psychosis (n = 439), and a comparison group from the general population (n = 1759) matched on age, sex, and postal code. We followed the cohort for 10 years to ascertain the prevalence of multimorbidity. We compared people with and without psychosis using modified Poisson regression models, and explored risk factors for multimorbidity among those with psychotic disorders. Results: People with psychotic disorders may have a 26% higher prevalence of multimorbidity 10 years following first diagnosis, although our findings include the possibility of a null effect (PR = 1.26, 95% CI 0.96–1.66). People with psychosis living in areas with the highest levels of material deprivation had a threefold higher prevalence of multimorbidity as compared to those in the lowest areas of material deprivation (PR = 3.09, 95% CI 1.21–7.90). Conclusion: Multimorbidity is prevalent among those with psychosis, and assessment for chronic health conditions should be integrated into clinical care for younger populations with psychotic illness.
AB - Aims: The higher prevalence of chronic physical health conditions among people with psychotic disorders may result in a reduced life expectancy as compared to the general population. More research is needed on the risk of multiple co-occurring chronic health conditions, known as multimorbidity, for people with psychotic disorders. Methods: We conducted a matched retrospective cohort study to quantify the prevalence of multimorbidity and associated factors among people with psychotic disorders over the 10-year period following first diagnosis, relative to those without psychosis. Data from an early psychosis intervention program in London, Canada were linked to population-based health administrative data to identify patients with first-episode psychosis (n = 439), and a comparison group from the general population (n = 1759) matched on age, sex, and postal code. We followed the cohort for 10 years to ascertain the prevalence of multimorbidity. We compared people with and without psychosis using modified Poisson regression models, and explored risk factors for multimorbidity among those with psychotic disorders. Results: People with psychotic disorders may have a 26% higher prevalence of multimorbidity 10 years following first diagnosis, although our findings include the possibility of a null effect (PR = 1.26, 95% CI 0.96–1.66). People with psychosis living in areas with the highest levels of material deprivation had a threefold higher prevalence of multimorbidity as compared to those in the lowest areas of material deprivation (PR = 3.09, 95% CI 1.21–7.90). Conclusion: Multimorbidity is prevalent among those with psychosis, and assessment for chronic health conditions should be integrated into clinical care for younger populations with psychotic illness.
KW - Co-occurring chronic conditions
KW - Comorbidity
KW - Multimorbidity
KW - Multiple chronic conditions
KW - Psychotic disorders
UR - http://www.scopus.com/inward/record.url?scp=85112597330&partnerID=8YFLogxK
UR - https://www.ncbi.nlm.nih.gov/pubmed/34357406
U2 - 10.1007/s00127-021-02157-y
DO - 10.1007/s00127-021-02157-y
M3 - Article
C2 - 34357406
AN - SCOPUS:85112597330
SN - 0933-7954
VL - 57
SP - 495
EP - 503
JO - Social Psychiatry and Psychiatric Epidemiology
JF - Social Psychiatry and Psychiatric Epidemiology
IS - 3
ER -