TY - JOUR
T1 - The paradox of senescent-marker positive cancer cells
T2 - challenges and opportunities
AU - O’Sullivan, Emily A.
AU - Wallis, Ryan
AU - Mossa, Federica
AU - Bishop, Cleo L.
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - Senescence is an anti-tumour mechanism and hallmark of cancer. Loss or mutation of key senescence effectors, such as p16INK4A, are frequently observed in cancer. Intriguingly, some human tumours are both proliferative and senescent-marker positive (Sen-Mark+). Here, we explore this paradox, focusing on the prognostic consequences and the current challenges in classifying these cells. We discuss future strategies for Sen-Mark+ cell detection together with emerging opportunities to exploit senescence for cancer.
AB - Senescence is an anti-tumour mechanism and hallmark of cancer. Loss or mutation of key senescence effectors, such as p16INK4A, are frequently observed in cancer. Intriguingly, some human tumours are both proliferative and senescent-marker positive (Sen-Mark+). Here, we explore this paradox, focusing on the prognostic consequences and the current challenges in classifying these cells. We discuss future strategies for Sen-Mark+ cell detection together with emerging opportunities to exploit senescence for cancer.
UR - https://www.scopus.com/pages/publications/85203972077
U2 - 10.1038/s41514-024-00168-y
DO - 10.1038/s41514-024-00168-y
M3 - Review article
AN - SCOPUS:85203972077
SN - 2731-6068
VL - 10
JO - npj Aging
JF - npj Aging
IS - 1
M1 - 41
ER -