The origin of the cancer stem cell: Current controversies and new insights

Rolf Bjerkvig; Berit B. Tysnes; Karen S. Aboody; Joseph Najbauer; A. J.A. Terzis

doi:10.1038/nrc1740

The origin of the cancer stem cell: Current controversies and new insights

Rolf Bjerkvig^*, Berit B. Tysnes, Karen S. Aboody, Joseph Najbauer, A. J.A. Terzis

^*Corresponding author for this work

Department of Cancer Research

Research output: Contribution to journal › Review article › peer-review

515 Citations (Scopus)

Abstract

Most tumours are derived from a single cell that is transformed into a cancer-initiating cell (cancer stem cell) that has the capacity to proliferate and form tumours in vivo. However, the origin of the cancer stem cell remains elusive. Interestingly, during development and tissue repair the fusion of genetic and cytoplasmic material between cells of different origins is an important physiological process. Such cell fusion and horizontal gene-transfer events have also been linked to several fundamental features of cancer and could be important in the development of the cancer stem cell.

Original language	English
Pages (from-to)	899-904
Number of pages	6
Journal	Nature Reviews Cancer
Volume	5
Issue number	11
DOIs	https://doi.org/10.1038/nrc1740
Publication status	Published - Nov 2005

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title = "The origin of the cancer stem cell: Current controversies and new insights",

abstract = "Most tumours are derived from a single cell that is transformed into a cancer-initiating cell (cancer stem cell) that has the capacity to proliferate and form tumours in vivo. However, the origin of the cancer stem cell remains elusive. Interestingly, during development and tissue repair the fusion of genetic and cytoplasmic material between cells of different origins is an important physiological process. Such cell fusion and horizontal gene-transfer events have also been linked to several fundamental features of cancer and could be important in the development of the cancer stem cell.",

author = "Rolf Bjerkvig and Tysnes, {Berit B.} and Aboody, {Karen S.} and Joseph Najbauer and Terzis, {A. J.A.}",

note = "Funding Information: We acknowledge the Norwegian Cancer Society, the Norwegian Research Council, Centre Recherche Public Sant{\'e}, Luxembourg, Helse Vest Haukeland Hospital, Bergen, Norway, City of Hope National Medical Center and Beckman Research Institute, and the Stop Cancer Foundation, California, USA.",

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AU - Najbauer, Joseph

AU - Terzis, A. J.A.

N1 - Funding Information: We acknowledge the Norwegian Cancer Society, the Norwegian Research Council, Centre Recherche Public Santé, Luxembourg, Helse Vest Haukeland Hospital, Bergen, Norway, City of Hope National Medical Center and Beckman Research Institute, and the Stop Cancer Foundation, California, USA.

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AB - Most tumours are derived from a single cell that is transformed into a cancer-initiating cell (cancer stem cell) that has the capacity to proliferate and form tumours in vivo. However, the origin of the cancer stem cell remains elusive. Interestingly, during development and tissue repair the fusion of genetic and cytoplasmic material between cells of different origins is an important physiological process. Such cell fusion and horizontal gene-transfer events have also been linked to several fundamental features of cancer and could be important in the development of the cancer stem cell.

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The origin of the cancer stem cell: Current controversies and new insights

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