The origin of the cancer stem cell: Current controversies and new insights

Rolf Bjerkvig*, Berit B. Tysnes, Karen S. Aboody, Joseph Najbauer, A. J.A. Terzis

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

480 Citations (Scopus)

Abstract

Most tumours are derived from a single cell that is transformed into a cancer-initiating cell (cancer stem cell) that has the capacity to proliferate and form tumours in vivo. However, the origin of the cancer stem cell remains elusive. Interestingly, during development and tissue repair the fusion of genetic and cytoplasmic material between cells of different origins is an important physiological process. Such cell fusion and horizontal gene-transfer events have also been linked to several fundamental features of cancer and could be important in the development of the cancer stem cell.

Original languageEnglish
Pages (from-to)899-904
Number of pages6
JournalNature Reviews Cancer
Volume5
Issue number11
DOIs
Publication statusPublished - Nov 2005

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