The multiple roles of actin-binding proteins at invadopodia

Takouhie Mgrditchian, Gabriele Sakalauskaite, Tanja Müller, Céline Hoffmann, Clément Thomas*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Invadopodia are actin-rich membrane protrusions that facilitate cancer cell dissemination by focusing on proteolytic activity and clearing paths for migration through physical barriers, such as basement membranes, dense extracellular matrices, and endothelial cell junctions. Invadopodium formation and activity require spatially and temporally regulated changes in actin filament organization and dynamics. About three decades of research have led to a remarkable understanding of how these changes are orchestrated by sequential recruitment and coordinated activity of different sets of actin-binding proteins. In this chapter, we provide an update on the roles of the actin cytoskeleton during the main stages of invadopodium development with a particular focus on actin polymerization machineries and production of pushing forces driving extracellular matrix remodeling.

Original languageEnglish
Pages (from-to)99-132
Number of pages34
JournalInternational review of cell and molecular biology
Volume360
DOIs
Publication statusPublished - Jan 2021

Keywords

  • Actin
  • Actin-binding protein
  • Cancer
  • Cytoskeleton
  • Invadopodia
  • Invasion
  • Metastasis

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