TY - JOUR
T1 - The multiple roles of actin-binding proteins at invadopodia
AU - Mgrditchian, Takouhie
AU - Sakalauskaite, Gabriele
AU - Müller, Tanja
AU - Hoffmann, Céline
AU - Thomas, Clément
N1 - Funding Information:
Thomas's lab is supported by grants from the National Research Fund (FNR, ACTIVATION C19/BM/13579644), La Fondation Cancer Luxembourg (ACTIMMUNE, FC/2019/02), and Think Pink Lux (Marian Aldred Award). T. Mgrditchian is the recipient of a postdoctoral fellowship from Fonds De La Recherche Scientifique (CRP2-TME, FNRS, TLV/7.4537.19). T. Müller. is supported by the National Research Fund (FNR PEARL P16/BM/11192868). Fig. 1 has been created with BioRender.
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/1
Y1 - 2021/1
N2 - Invadopodia are actin-rich membrane protrusions that facilitate cancer cell dissemination by focusing on proteolytic activity and clearing paths for migration through physical barriers, such as basement membranes, dense extracellular matrices, and endothelial cell junctions. Invadopodium formation and activity require spatially and temporally regulated changes in actin filament organization and dynamics. About three decades of research have led to a remarkable understanding of how these changes are orchestrated by sequential recruitment and coordinated activity of different sets of actin-binding proteins. In this chapter, we provide an update on the roles of the actin cytoskeleton during the main stages of invadopodium development with a particular focus on actin polymerization machineries and production of pushing forces driving extracellular matrix remodeling.
AB - Invadopodia are actin-rich membrane protrusions that facilitate cancer cell dissemination by focusing on proteolytic activity and clearing paths for migration through physical barriers, such as basement membranes, dense extracellular matrices, and endothelial cell junctions. Invadopodium formation and activity require spatially and temporally regulated changes in actin filament organization and dynamics. About three decades of research have led to a remarkable understanding of how these changes are orchestrated by sequential recruitment and coordinated activity of different sets of actin-binding proteins. In this chapter, we provide an update on the roles of the actin cytoskeleton during the main stages of invadopodium development with a particular focus on actin polymerization machineries and production of pushing forces driving extracellular matrix remodeling.
KW - Actin
KW - Actin-binding protein
KW - Cancer
KW - Cytoskeleton
KW - Invadopodia
KW - Invasion
KW - Metastasis
UR - http://www.scopus.com/inward/record.url?scp=85104061708&partnerID=8YFLogxK
UR - https://www.ncbi.nlm.nih.gov/pubmed/33962752
U2 - 10.1016/bs.ircmb.2021.03.004
DO - 10.1016/bs.ircmb.2021.03.004
M3 - Article
C2 - 33962752
AN - SCOPUS:85104061708
SN - 1937-6448
VL - 360
SP - 99
EP - 132
JO - International review of cell and molecular biology
JF - International review of cell and molecular biology
ER -