TY - JOUR
T1 - The microbiome-gut-brain axis in acute and chronic brain diseases
AU - Benakis, Corinne
AU - Martin-Gallausiaux, Camille
AU - Trezzi, Jean Pierre
AU - Melton, Philip
AU - Liesz, Arthur
AU - Wilmes, Paul
N1 - Funding Information:
This work was supported by the Luxembourg Fonds National de la Recherche (FNR) under grants CORE/BM/11333923 and AFR/Bilateral-RIKEN/11228553-4 and the Michael J. Fox Foundation under grant No. 14701 to PW; by the German Research Foundation (DFG, LI2534/2-1 ), the European Research Council ( ERC-StG 802305 ) and the Munich Cluster for Systems Neurology (EXC 2145 SyNergy) to AL and by the European Marie Sklodowska-Curie grant agreement No 753893 to CB.
Publisher Copyright:
© 2019 The Authors
PY - 2020/4
Y1 - 2020/4
N2 - The gut microbiome — the largest reservoir of microorganisms of the human body — is emerging as an important player in neurodevelopment and ageing as well as in brain diseases including stroke, Alzheimer's disease and Parkinson's disease. The growing knowledge on mediators and triggered pathways has advanced our understanding of the interactions along the gut-brain axis. Gut bacteria produce neuroactive compounds and can modulate neuronal function, plasticity and behavior. Furthermore, intestinal microorganisms impact the host's metabolism and immune status which in turn affect neuronal pathways in the enteric and central nervous systems. Here, we discuss the recent insights from human studies and animal models on the bi-directional communication along the microbiome-gut-brain axis in both acute and chronic brain diseases.
AB - The gut microbiome — the largest reservoir of microorganisms of the human body — is emerging as an important player in neurodevelopment and ageing as well as in brain diseases including stroke, Alzheimer's disease and Parkinson's disease. The growing knowledge on mediators and triggered pathways has advanced our understanding of the interactions along the gut-brain axis. Gut bacteria produce neuroactive compounds and can modulate neuronal function, plasticity and behavior. Furthermore, intestinal microorganisms impact the host's metabolism and immune status which in turn affect neuronal pathways in the enteric and central nervous systems. Here, we discuss the recent insights from human studies and animal models on the bi-directional communication along the microbiome-gut-brain axis in both acute and chronic brain diseases.
UR - http://www.scopus.com/inward/record.url?scp=85076024500&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2019.11.009
DO - 10.1016/j.conb.2019.11.009
M3 - Review article
C2 - 31812830
AN - SCOPUS:85076024500
SN - 0959-4388
VL - 61
SP - 1
EP - 9
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -