The Luxembourg Parkinson's Study: A comprehensive approach for stratification and early diagnosis

Geraldine Hipp*, Michel Vaillant, Nico J. Diederich, Kirsten Roomp, Venkata P. Satagopam, Peter Banda, Estelle Sandt, Kathleen Mommaerts, Sabine K. Schmitz, Laura Longhino, Alexandra Schweicher, Anne Marie Hanff, Béatrice Nicolai, Pierre Kolber, Dorothea Reiter, Lukas Pavelka, Sylvia Binck, Claire Pauly, Lars Geffers, Fay BetsouManon Gantenbein, Jochen Klucken, Thomas Gasser, Michele T. Hu, Rudi Balling, Rejko Krüger

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Abstract

While genetic advances have successfully defined part of the complexity in Parkinson's disease (PD), the clinical characterization of phenotypes remains challenging. Therapeutic trials and cohort studies typically include patients with earlier disease stages and exclude comorbidities, thus ignoring a substantial part of the real-world PD population. To account for these limitations, we implemented the Luxembourg PD study as a comprehensive clinical, molecular and device-based approach including patients with typical PD and atypical parkinsonism, irrespective of their disease stage, age, comorbidities, or linguistic background. To provide a large, longitudinally followed, and deeply phenotyped set of patients and controls for clinical and fundamental research on PD, we implemented an open-source digital platform that can be harmonized with international PD cohort studies. Our interests also reflect Luxembourg-specific areas of PD research, including vision, gait, and cognition. This effort is flanked by comprehensive biosampling efforts assuring high quality and sustained availability of body liquids and tissue biopsies. We provide evidence for the feasibility of such a cohort program with deep phenotyping and high quality biosampling on parkinsonism in an environment with structural specificities and alert the international research community to our willingness to collaborate with other centers. The combination of advanced clinical phenotyping approaches including device-based assessment will create a comprehensive assessment of the disease and its variants, its interaction with comorbidities and its progression. We envision the Luxembourg Parkinson's study as an important research platform for defining early diagnosis and progression markers that translate into stratified treatment approaches.

Original languageEnglish
Article number326
JournalFrontiers in Aging Neuroscience
Volume10
DOIs
Publication statusPublished - 2018

Keywords

  • Cohort
  • Deep phenotyping
  • Longitudinal
  • Parkinsonism
  • Stratification

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