The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila

Catherine Dostert, Emmanuelle Jouanguy, Phil Irving, Laurent Troxler, Delphine Galiana-Arnoux, Charles Hetru, Jules A. Hoffmann, Jean Luc Imler*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

469 Citations (Scopus)

Abstract

The response of drosophila to bacterial and fungal infections involves two signaling pathways, Toll and Imd, which both activate members of the transcription factor NF-κB family. Here we have studied the global transcriptional response of flies to infection with drosophila C virus. Viral infection induced a set of genes distinct from those regulated by the Toll or Imd pathways and triggered a signal transducer and activator of transcription (STAT) DNA-binding activity. Genetic experiments showed that the Jak kinase Hopscotch was involved in the control of the viral load in infected flies and was required but not sufficient for the induction of some virus-regulated genes. Our results indicate that in addition to Toll and Imd, a third, evolutionary conserved innate immunity pathway functions in drosophila and counters viral infection.

Original languageEnglish
Pages (from-to)946-953
Number of pages8
JournalNature Immunology
Volume6
Issue number9
DOIs
Publication statusPublished - Sep 2005
Externally publishedYes

Fingerprint

Dive into the research topics of 'The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila'. Together they form a unique fingerprint.

Cite this