The invasive proteome of glioblastoma revealed by laser-capture microdissection

Thomas Daubon, Joris Guyon, Anne Aurélie Raymond, Benjamin Dartigues, Justine Rudewicz, Zakaria Ezzoukhry, Jean William Dupuy, John M.J. Herbert, Frédéric Saltel, Rolf Bjerkvig, Macha Nikolski, Andreas Bikfalvi*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

Background: Glioblastomas are heterogeneous tumors composed of a necrotic and tumor core and an invasive periphery.

Methods: Here, we performed a proteomics analysis of laser-capture micro-dissected glioblastoma core and invasive areas of patient-derived xenografts.

Results: Bioinformatics analysis identified enriched proteins in central and invasive tumor areas. Novel markers of invasion were identified, the genes proteolipid protein 1 (PLP1) and Dynamin-1 (DNM1), which were subsequently validated in tumors and by functional assays.

Conclusions: In summary, our results identify new networks and molecules that may play an important role in glioblastoma development and may constitute potential novel therapeutic targets.

Original languageEnglish
Article numbervdz029
JournalNeuro-Oncology Advances
Volume1
Issue number1
DOIs
Publication statusPublished - May 2019

Keywords

  • glioblastoma
  • intratumor heterogeneity
  • invasion
  • patient-derived xenograft
  • proteomics analysis

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