The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk

Daniele Campa; Anika Hüsing; James D. McKay; Olga Sinilnikova; Ulla Vogel; Anne Tjønneland; Kim Overvad; Jakob Stegger; Françoise Clavel-Chapelon; Nathalie Chabbert-Buffet; Guy Fagherazzi; Antonia Trichopoulou; Dimosthenis Zylis; Erifili Oustoglou; Sabine Rohrmann; Birgit Teucher; Eva Fisher; Heiner Boeing; Giovanna Masala; Vittorio Krogh; Carlotta Sacerdote; Salvatore Panico; Rosario Tumino; N. Charlotte Onland-Moret; Carla H. van Gils; H. B. Bueno-de-Mesquita; Eiliv Lund; María D. Chirlaque; Núria Sala; José R. Quirós; Eva Ardanaz; Pilar Amiano; Esther Molina-Montes; Göran Hallmans; Per Lenner; Ruth C. Travis; Timothy J. Key; Nick Wareham; Kay Tee Khaw; Sabina Rinaldi; Nadia Slimani; Veronique Chajes; Afshan Siddiq; Elio Riboli; Rudolf Kaaks; Federico Canzian

doi:10.1186/1471-2407-10-563

The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk

Daniele Campa, Anika Hüsing, James D. McKay, Olga Sinilnikova, Ulla Vogel, Anne Tjønneland, Kim Overvad, Jakob Stegger, Françoise Clavel-Chapelon, Nathalie Chabbert-Buffet, Guy Fagherazzi, Antonia Trichopoulou, Dimosthenis Zylis, Erifili Oustoglou, Sabine Rohrmann, Birgit Teucher, Eva Fisher, Heiner Boeing, Giovanna Masala, Vittorio KroghCarlotta Sacerdote, Salvatore Panico, Rosario Tumino, N. Charlotte Onland-Moret, Carla H. van Gils, H. B. Bueno-de-Mesquita, Eiliv Lund, María D. Chirlaque, Núria Sala, José R. Quirós, Eva Ardanaz, Pilar Amiano, Esther Molina-Montes, Göran Hallmans, Per Lenner, Ruth C. Travis, Timothy J. Key, Nick Wareham, Kay Tee Khaw, Sabina Rinaldi, Nadia Slimani, Veronique Chajes, Afshan Siddiq, Elio Riboli, Rudolf Kaaks, Federico Canzian^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

Abstract

Background: The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings. BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC).Methods: we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk.Results and Conclusions: In this study we were not able to find any statistically significant association between this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast cancer overall and by subgroups of age, or menopausal status.

Original language	English
Article number	563
Journal	BMC Cancer
Volume	10
DOIs	https://doi.org/10.1186/1471-2407-10-563
Publication status	Published - 18 Oct 2010
Externally published	Yes

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Campa, D., Hüsing, A., McKay, J. D., Sinilnikova, O., Vogel, U., Tjønneland, A., Overvad, K., Stegger, J., Clavel-Chapelon, F., Chabbert-Buffet, N., Fagherazzi, G., Trichopoulou, A., Zylis, D., Oustoglou, E., Rohrmann, S., Teucher, B., Fisher, E., Boeing, H., Masala, G., ... Canzian, F. (2010). The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk. BMC Cancer, 10, Article 563. https://doi.org/10.1186/1471-2407-10-563

@article{9ce1ba7636664b2aa01e6c0d0d398a69,

title = "The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk",

abstract = "Background: The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings. BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC).Methods: we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk.Results and Conclusions: In this study we were not able to find any statistically significant association between this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast cancer overall and by subgroups of age, or menopausal status.",

author = "Daniele Campa and Anika H{\"u}sing and McKay, {James D.} and Olga Sinilnikova and Ulla Vogel and Anne Tj{\o}nneland and Kim Overvad and Jakob Stegger and Fran{\c c}oise Clavel-Chapelon and Nathalie Chabbert-Buffet and Guy Fagherazzi and Antonia Trichopoulou and Dimosthenis Zylis and Erifili Oustoglou and Sabine Rohrmann and Birgit Teucher and Eva Fisher and Heiner Boeing and Giovanna Masala and Vittorio Krogh and Carlotta Sacerdote and Salvatore Panico and Rosario Tumino and Onland-Moret, {N. Charlotte} and {van Gils}, {Carla H.} and Bueno-de-Mesquita, {H. B.} and Eiliv Lund and Chirlaque, {Mar{\'i}a D.} and N{\'u}ria Sala and Quir{\'o}s, {Jos{\'e} R.} and Eva Ardanaz and Pilar Amiano and Esther Molina-Montes and G{\"o}ran Hallmans and Per Lenner and Travis, {Ruth C.} and Key, {Timothy J.} and Nick Wareham and Khaw, {Kay Tee} and Sabina Rinaldi and Nadia Slimani and Veronique Chajes and Afshan Siddiq and Elio Riboli and Rudolf Kaaks and Federico Canzian",

note = "Funding Information: Funds; Dutch ZON (Zorg Onderzoek Nederland); World Cancer Research Fund (WCRF); Swedish Cancer Society; Swedish Scientific Council; Regional Government of Skane, Sweden; Norwegian Cancer Society. Funding Information: The EPIC study was funded by “Europe Against Cancer” Programme of the European Commission (SANCO); Ligue contre le Cancer (France); Institut Gustave Roussy (France); Mutuelle G{\'e}n{\'e}rale de l{\textquoteright}Education Nationale; Institut National de la Sant{\'e} et de la Recherche M{\'e}dicale (INSERM); German Cancer Aid; German Cancer Research Center; German Federal Ministry of Education and Research; Danish Cancer Society; Health Research Fund (FIS) of the Spanish Ministry of Health; the participating regional governments and institutions of Spain; Cancer Research UK; Medical Research Council, UK; the Stroke Association, UK; British Heart Foundation; Department of Health, UK; Food Standards Agency, UK; the Wellcome Trust, UK; Greek Ministry of Health and Social Solidarity; Hellenic Health Foundation and Stavros Niarchos Foundation; Italian Association for Research on Cancer; Italian National Research Council; Dutch Ministry of Public Health, Welfare and Sports; Dutch Ministry of Health; Dutch Prevention Funds; LK Research",

year = "2010",

month = oct,

day = "18",

doi = "10.1186/1471-2407-10-563",

language = "English",

volume = "10",

journal = "BMC Cancer",

issn = "1471-2407",

publisher = "BioMed Central Ltd.",

}

Campa, D, Hüsing, A, McKay, JD, Sinilnikova, O, Vogel, U, Tjønneland, A, Overvad, K, Stegger, J, Clavel-Chapelon, F, Chabbert-Buffet, N, Fagherazzi, G, Trichopoulou, A, Zylis, D, Oustoglou, E, Rohrmann, S, Teucher, B, Fisher, E, Boeing, H, Masala, G, Krogh, V, Sacerdote, C, Panico, S, Tumino, R, Onland-Moret, NC, van Gils, CH, Bueno-de-Mesquita, HB, Lund, E, Chirlaque, MD, Sala, N, Quirós, JR, Ardanaz, E, Amiano, P, Molina-Montes, E, Hallmans, G, Lenner, P, Travis, RC, Key, TJ, Wareham, N, Khaw, KT, Rinaldi, S, Slimani, N, Chajes, V, Siddiq, A, Riboli, E, Kaaks, R & Canzian, F 2010, 'The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk', BMC Cancer, vol. 10, 563. https://doi.org/10.1186/1471-2407-10-563

TY - JOUR

T1 - The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk

AU - Campa, Daniele

AU - Hüsing, Anika

AU - McKay, James D.

AU - Sinilnikova, Olga

AU - Vogel, Ulla

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Stegger, Jakob

AU - Clavel-Chapelon, Françoise

AU - Chabbert-Buffet, Nathalie

AU - Fagherazzi, Guy

AU - Trichopoulou, Antonia

AU - Zylis, Dimosthenis

AU - Oustoglou, Erifili

AU - Rohrmann, Sabine

AU - Teucher, Birgit

AU - Fisher, Eva

AU - Boeing, Heiner

AU - Masala, Giovanna

AU - Krogh, Vittorio

AU - Sacerdote, Carlotta

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Onland-Moret, N. Charlotte

AU - van Gils, Carla H.

AU - Bueno-de-Mesquita, H. B.

AU - Lund, Eiliv

AU - Chirlaque, María D.

AU - Sala, Núria

AU - Quirós, José R.

AU - Ardanaz, Eva

AU - Amiano, Pilar

AU - Molina-Montes, Esther

AU - Hallmans, Göran

AU - Lenner, Per

AU - Travis, Ruth C.

AU - Key, Timothy J.

AU - Wareham, Nick

AU - Khaw, Kay Tee

AU - Rinaldi, Sabina

AU - Slimani, Nadia

AU - Chajes, Veronique

AU - Siddiq, Afshan

AU - Riboli, Elio

AU - Kaaks, Rudolf

AU - Canzian, Federico

N1 - Funding Information: Funds; Dutch ZON (Zorg Onderzoek Nederland); World Cancer Research Fund (WCRF); Swedish Cancer Society; Swedish Scientific Council; Regional Government of Skane, Sweden; Norwegian Cancer Society. Funding Information: The EPIC study was funded by “Europe Against Cancer” Programme of the European Commission (SANCO); Ligue contre le Cancer (France); Institut Gustave Roussy (France); Mutuelle Générale de l’Education Nationale; Institut National de la Santé et de la Recherche Médicale (INSERM); German Cancer Aid; German Cancer Research Center; German Federal Ministry of Education and Research; Danish Cancer Society; Health Research Fund (FIS) of the Spanish Ministry of Health; the participating regional governments and institutions of Spain; Cancer Research UK; Medical Research Council, UK; the Stroke Association, UK; British Heart Foundation; Department of Health, UK; Food Standards Agency, UK; the Wellcome Trust, UK; Greek Ministry of Health and Social Solidarity; Hellenic Health Foundation and Stavros Niarchos Foundation; Italian Association for Research on Cancer; Italian National Research Council; Dutch Ministry of Public Health, Welfare and Sports; Dutch Ministry of Health; Dutch Prevention Funds; LK Research

PY - 2010/10/18

Y1 - 2010/10/18

N2 - Background: The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings. BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC).Methods: we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk.Results and Conclusions: In this study we were not able to find any statistically significant association between this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast cancer overall and by subgroups of age, or menopausal status.

AB - Background: The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings. BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC).Methods: we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk.Results and Conclusions: In this study we were not able to find any statistically significant association between this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast cancer overall and by subgroups of age, or menopausal status.

UR - http://www.scopus.com/inward/record.url?scp=77957917514&partnerID=8YFLogxK

U2 - 10.1186/1471-2407-10-563

DO - 10.1186/1471-2407-10-563

M3 - Article

C2 - 20955599

AN - SCOPUS:77957917514

SN - 1471-2407

VL - 10

JO - BMC Cancer

JF - BMC Cancer

M1 - 563

ER -

The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk

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