The inhibition of TNF-α-induced NF-κB activation by marine natural products

Florence Folmer, Marcel Jaspars, Godofredo Solano, Silvia Cristofanon, Estelle Henry, Jioji Tabudravu, Kenny Black, David H. Green, Frithjof C. Küpper, William Aalbersberg, Klaus Feussner, Mario Dicato, Marc Diederich*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)


The deregulated activation of NF-κB is associated with cancer development and inflammatory diseases. With an aim to find new NF-κB inhibitors, we purified and characterized compounds from extracts of the Fijian sponge Rhabdastrella globostellata, the crinoid Comanthus parvicirrus, the soft corals Sarcophyton sp. nov. and Sinularia sp., and the gorgonian Subergorgia sp. after an initial screening of 266 extracts from different marine origins. Results obtained show that selected purified compounds had a cytotoxic effect on the human leukaemia cell line K562, inhibited both TNF-α-induced NF-κB-DNA binding as well as TNF-α-induced IκBα degradation and nuclear translocation of p50/p65. Furthermore, we observed the inhibition of NF-κB activation induced by an overexpression of IKKβ. Interestingly, natural products inhibited IKKβ kinase as well as the 26S proteasome proteolytic activity.

Original languageEnglish
Pages (from-to)592-606
Number of pages15
JournalBiochemical Pharmacology
Issue number6
Publication statusPublished - 15 Sept 2009
Externally publishedYes


  • Anti-cancer drug discovery
  • Marine natural product
  • NF-κB


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