The influence of TNF alpha -308 G/A polymorphism on oxidative stress in patients with chronic lymphocytic leukemia

T. Jevtovic-Stoimenov; T. Cvetkovic; M. Despotovic; J. Basic; J. Cvetkovic; G. Marjanovic; D. Pavlovic

doi:10.1016/j.leukres.2017.01.018

The influence of TNF alpha -308 G/A polymorphism on oxidative stress in patients with chronic lymphocytic leukemia

T. Jevtovic-Stoimenov^*, T. Cvetkovic, M. Despotovic, J. Basic, J. Cvetkovic, G. Marjanovic, D. Pavlovic

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Abstract

The aim of this study was to examine the association of TNF-α-308G/A polymorphism with CLL and influence on oxidative stress parameters.Significant difference in the genotype and allele distribution was obtained in TNFA subgroup of patients.Significantly higher GPx activity and TBARS and lower catalase activity were detected in CLL.Significantly higher catalase and lower GPx activities were detected in PBMC of TNFG compared to TNFA subgroup, while TBARS were higher in TNFA.Oxidative stress in CLL patients highly correlates with the presence of TNFA subgroup. Increased TBARS, GPx and decreased catalase activity are associated with TNF-α-308A allele containing genotypes.

Original language	English
Pages (from-to)	66-72
Number of pages	7
Journal	Leukemia Research
Volume	54
DOIs	https://doi.org/10.1016/j.leukres.2017.01.018
Publication status	Published - 1 Mar 2017
Externally published	Yes

Keywords

CLL
Oxidative stress
TNF-α polymorphism

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10.1016/j.leukres.2017.01.018

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title = "The influence of TNF alpha -308 G/A polymorphism on oxidative stress in patients with chronic lymphocytic leukemia",

abstract = "The aim of this study was to examine the association of TNF-α-308G/A polymorphism with CLL and influence on oxidative stress parameters.Significant difference in the genotype and allele distribution was obtained in TNFA subgroup of patients.Significantly higher GPx activity and TBARS and lower catalase activity were detected in CLL.Significantly higher catalase and lower GPx activities were detected in PBMC of TNFG compared to TNFA subgroup, while TBARS were higher in TNFA.Oxidative stress in CLL patients highly correlates with the presence of TNFA subgroup. Increased TBARS, GPx and decreased catalase activity are associated with TNF-α-308A allele containing genotypes.",

keywords = "CLL, Oxidative stress, TNF-α polymorphism",

author = "T. Jevtovic-Stoimenov and T. Cvetkovic and M. Despotovic and J. Basic and J. Cvetkovic and G. Marjanovic and D. Pavlovic",

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doi = "10.1016/j.leukres.2017.01.018",

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TY - JOUR

T1 - The influence of TNF alpha -308 G/A polymorphism on oxidative stress in patients with chronic lymphocytic leukemia

AU - Jevtovic-Stoimenov, T.

AU - Cvetkovic, T.

AU - Despotovic, M.

AU - Basic, J.

AU - Cvetkovic, J.

AU - Marjanovic, G.

AU - Pavlovic, D.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - The aim of this study was to examine the association of TNF-α-308G/A polymorphism with CLL and influence on oxidative stress parameters.Significant difference in the genotype and allele distribution was obtained in TNFA subgroup of patients.Significantly higher GPx activity and TBARS and lower catalase activity were detected in CLL.Significantly higher catalase and lower GPx activities were detected in PBMC of TNFG compared to TNFA subgroup, while TBARS were higher in TNFA.Oxidative stress in CLL patients highly correlates with the presence of TNFA subgroup. Increased TBARS, GPx and decreased catalase activity are associated with TNF-α-308A allele containing genotypes.

AB - The aim of this study was to examine the association of TNF-α-308G/A polymorphism with CLL and influence on oxidative stress parameters.Significant difference in the genotype and allele distribution was obtained in TNFA subgroup of patients.Significantly higher GPx activity and TBARS and lower catalase activity were detected in CLL.Significantly higher catalase and lower GPx activities were detected in PBMC of TNFG compared to TNFA subgroup, while TBARS were higher in TNFA.Oxidative stress in CLL patients highly correlates with the presence of TNFA subgroup. Increased TBARS, GPx and decreased catalase activity are associated with TNF-α-308A allele containing genotypes.

KW - CLL

KW - Oxidative stress

KW - TNF-α polymorphism

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U2 - 10.1016/j.leukres.2017.01.018

DO - 10.1016/j.leukres.2017.01.018

M3 - Article

C2 - 28113108

AN - SCOPUS:85010015841

SN - 0145-2126

VL - 54

SP - 66

EP - 72

JO - Leukemia Research

JF - Leukemia Research

ER -

The influence of TNF alpha -308 G/A polymorphism on oxidative stress in patients with chronic lymphocytic leukemia

Abstract

Keywords

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