The inflammasome: a danger sensing complex triggering innate immunity

Virginie Pétrilli; Catherine Dostert; Daniel A. Muruve; Jürg Tschopp

doi:10.1016/j.coi.2007.09.002

The inflammasome: a danger sensing complex triggering innate immunity

Virginie Pétrilli^*, Catherine Dostert, Daniel A. Muruve, Jürg Tschopp

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

580 Citations (Scopus)

Abstract

The NOD-like receptors (NLR) are a family of intracellular sensors of microbial motifs and 'danger signals' that have emerged as being crucial components of the innate immune responses and inflammation. Several NLRs (NALPs and IPAF) form a caspase-1-activating multiprotein complex, termed inflammasome, that processes proinflammatory cytokines including IL-1β. Amongst the various inflammasomes, the NALP3 inflammasome is particularly qualified to sense a plethora of diverse molecules, ranging from bacterial muramyldipeptide to monosodium urate crystals. The important role of the NALP3 inflammasome is emphasized by the identification of mutations in the NALP3 gene that are associated with a susceptibility to inflammatory disorders. These and other issues related to the inflammasome are discussed in this review.

Original language	English
Pages (from-to)	615-622
Number of pages	8
Journal	Current Opinion in Immunology
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/j.coi.2007.09.002
Publication status	Published - Dec 2007
Externally published	Yes

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@article{8047317d5b4942509daf42ec6399e120,

title = "The inflammasome: a danger sensing complex triggering innate immunity",

abstract = "The NOD-like receptors (NLR) are a family of intracellular sensors of microbial motifs and 'danger signals' that have emerged as being crucial components of the innate immune responses and inflammation. Several NLRs (NALPs and IPAF) form a caspase-1-activating multiprotein complex, termed inflammasome, that processes proinflammatory cytokines including IL-1β. Amongst the various inflammasomes, the NALP3 inflammasome is particularly qualified to sense a plethora of diverse molecules, ranging from bacterial muramyldipeptide to monosodium urate crystals. The important role of the NALP3 inflammasome is emphasized by the identification of mutations in the NALP3 gene that are associated with a susceptibility to inflammatory disorders. These and other issues related to the inflammasome are discussed in this review.",

author = "Virginie P{\'e}trilli and Catherine Dostert and Muruve, {Daniel A.} and J{\"u}rg Tschopp",

note = "Funding Information: This work was supported by the Swiss Committee for Technology and Innovation, and MUGEN.",

year = "2007",

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doi = "10.1016/j.coi.2007.09.002",

language = "English",

volume = "19",

pages = "615--622",

journal = "Current Opinion in Immunology",

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TY - JOUR

T1 - The inflammasome

T2 - a danger sensing complex triggering innate immunity

AU - Pétrilli, Virginie

AU - Dostert, Catherine

AU - Muruve, Daniel A.

AU - Tschopp, Jürg

N1 - Funding Information: This work was supported by the Swiss Committee for Technology and Innovation, and MUGEN.

PY - 2007/12

Y1 - 2007/12

N2 - The NOD-like receptors (NLR) are a family of intracellular sensors of microbial motifs and 'danger signals' that have emerged as being crucial components of the innate immune responses and inflammation. Several NLRs (NALPs and IPAF) form a caspase-1-activating multiprotein complex, termed inflammasome, that processes proinflammatory cytokines including IL-1β. Amongst the various inflammasomes, the NALP3 inflammasome is particularly qualified to sense a plethora of diverse molecules, ranging from bacterial muramyldipeptide to monosodium urate crystals. The important role of the NALP3 inflammasome is emphasized by the identification of mutations in the NALP3 gene that are associated with a susceptibility to inflammatory disorders. These and other issues related to the inflammasome are discussed in this review.

AB - The NOD-like receptors (NLR) are a family of intracellular sensors of microbial motifs and 'danger signals' that have emerged as being crucial components of the innate immune responses and inflammation. Several NLRs (NALPs and IPAF) form a caspase-1-activating multiprotein complex, termed inflammasome, that processes proinflammatory cytokines including IL-1β. Amongst the various inflammasomes, the NALP3 inflammasome is particularly qualified to sense a plethora of diverse molecules, ranging from bacterial muramyldipeptide to monosodium urate crystals. The important role of the NALP3 inflammasome is emphasized by the identification of mutations in the NALP3 gene that are associated with a susceptibility to inflammatory disorders. These and other issues related to the inflammasome are discussed in this review.

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U2 - 10.1016/j.coi.2007.09.002

DO - 10.1016/j.coi.2007.09.002

M3 - Review article

C2 - 17977705

AN - SCOPUS:36849045915

SN - 0952-7915

VL - 19

SP - 615

EP - 622

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

IS - 6

ER -

The inflammasome: a danger sensing complex triggering innate immunity

Abstract

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