The impact of high anxiety level on the oxidative status of mouse peripheral blood lymphocytes, granulocytes and monocytes

Hassan Rammal, Jaouad Bouayed, Chafique Younos, Rachid Soulimani*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Abstract

Anxiety has been implicated in a number of psychiatric disorders, such as generalized anxiety disorder, depression, panic attacks, phobias, obsessive-compulsive disorders and posttraumatic stress disorders. In this study, we investigated the impact of high anxiety on the levels of intracellular reactive oxygen species in lymphocytes, granulocytes and monocytes from the peripheral blood of mice by using a 2′,7′-dichlorofluorescein diacetate (DCFH-DA) probe. The behavioural light/dark choice test was used to distinguish highly anxious from less anxious mice. Our results showed that a high anxiety level significantly increased the generation of reactive oxygen species in the peripheral blood lymphocytes, granulocytes and monocytes.

Original languageEnglish
Pages (from-to)173-175
Number of pages3
JournalEuropean Journal of Pharmacology
Volume589
Issue number1-3
DOIs
Publication statusPublished - 28 Jul 2008
Externally publishedYes

Keywords

  • Anxiety
  • Granulocyte
  • Light/dark test
  • Lymphocyte
  • Monocyte
  • Reactive oxygen species

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