TY - JOUR
T1 - The impact of high anxiety level on the oxidative status of mouse peripheral blood lymphocytes, granulocytes and monocytes
AU - Rammal, Hassan
AU - Bouayed, Jaouad
AU - Younos, Chafique
AU - Soulimani, Rachid
PY - 2008/7/28
Y1 - 2008/7/28
N2 - Anxiety has been implicated in a number of psychiatric disorders, such as generalized anxiety disorder, depression, panic attacks, phobias, obsessive-compulsive disorders and posttraumatic stress disorders. In this study, we investigated the impact of high anxiety on the levels of intracellular reactive oxygen species in lymphocytes, granulocytes and monocytes from the peripheral blood of mice by using a 2′,7′-dichlorofluorescein diacetate (DCFH-DA) probe. The behavioural light/dark choice test was used to distinguish highly anxious from less anxious mice. Our results showed that a high anxiety level significantly increased the generation of reactive oxygen species in the peripheral blood lymphocytes, granulocytes and monocytes.
AB - Anxiety has been implicated in a number of psychiatric disorders, such as generalized anxiety disorder, depression, panic attacks, phobias, obsessive-compulsive disorders and posttraumatic stress disorders. In this study, we investigated the impact of high anxiety on the levels of intracellular reactive oxygen species in lymphocytes, granulocytes and monocytes from the peripheral blood of mice by using a 2′,7′-dichlorofluorescein diacetate (DCFH-DA) probe. The behavioural light/dark choice test was used to distinguish highly anxious from less anxious mice. Our results showed that a high anxiety level significantly increased the generation of reactive oxygen species in the peripheral blood lymphocytes, granulocytes and monocytes.
KW - Anxiety
KW - Granulocyte
KW - Light/dark test
KW - Lymphocyte
KW - Monocyte
KW - Reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=47749091233&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2008.06.053
DO - 10.1016/j.ejphar.2008.06.053
M3 - Article
C2 - 18593579
AN - SCOPUS:47749091233
SN - 0014-2999
VL - 589
SP - 173
EP - 175
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-3
ER -