The human mdr1 (multidrug-resistance) gene harbours a long homopyrimidine·homopurine sequence next to a cluster of Alu repeated sequences in intron 14

Marc Pauly; Isabelle Kayser; Martine Schmitz; Fernand Ries; François Hentges; Mario Dicato

doi:10.1016/0378-1119(95)00716-J

The human mdr1 (multidrug-resistance) gene harbours a long homopyrimidine·homopurine sequence next to a cluster of Alu repeated sequences in intron 14

Marc Pauly^*
, Isabelle Kayser
, Martine Schmitz
, Fernand Ries
, François Hentges
, Mario Dicato

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Abstract

In order to identify specific DNA sequences useful as 'genetic landmarks' in the construction of a complete map of the human mdr1 (multidrug-resistance) gene, we investigated the introns in the central region. In intron 14, we identified a long stretch of a homopyrimidine·homopurine sequence most probably adopting an unconventional DNA conformation, followed by a cluster of three Alu repeated sequences in an inverted orientation. Here, we describe the structure, formation and nucleotide sequence of these DNA elements.

Original language	English
Pages (from-to)	299-300
Number of pages	2
Journal	Gene
Volume	153
Issue number	2
DOIs	https://doi.org/10.1016/0378-1119(95)00716-J
Publication status	Published - 14 Feb 1995
Externally published	Yes

Keywords

P-glycoprotein
gene cloning
gene mapping
nucleotide sequence
recombinant DNA
repetitive sequences

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10.1016/0378-1119(95)00716-J

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title = "The human mdr1 (multidrug-resistance) gene harbours a long homopyrimidine·homopurine sequence next to a cluster of Alu repeated sequences in intron 14",

abstract = "In order to identify specific DNA sequences useful as 'genetic landmarks' in the construction of a complete map of the human mdr1 (multidrug-resistance) gene, we investigated the introns in the central region. In intron 14, we identified a long stretch of a homopyrimidine·homopurine sequence most probably adopting an unconventional DNA conformation, followed by a cluster of three Alu repeated sequences in an inverted orientation. Here, we describe the structure, formation and nucleotide sequence of these DNA elements.",

keywords = "P-glycoprotein, gene cloning, gene mapping, nucleotide sequence, recombinant DNA, repetitive sequences",

author = "Marc Pauly and Isabelle Kayser and Martine Schmitz and Fernand Ries and Fran{\c c}ois Hentges and Mario Dicato",

note = "Funding Information: We thank Dr. I. Pastan (NIH, Bethesda, MD, USA) and Prof. P. Reizenstein (Karolinska Institute, Stockholm, Sweden) for the gift of probe 5A; Dr. A. Steinmetz, Prof. E. Westhof, J.-M. Garnier and Prof. P. Chambon (CNRS, Strasbourg, France) for the gift of the human genomic library and helpful suggestions. This work was supported by the Centre de Recherche Public de la Sant6 and the Fondation de Recherche Cancer et Sang of Luxembourg.",

year = "1995",

month = feb,

day = "14",

doi = "10.1016/0378-1119(95)00716-J",

language = "English",

volume = "153",

pages = "299--300",

journal = "Gene",

issn = "0378-1119",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - The human mdr1 (multidrug-resistance) gene harbours a long homopyrimidine·homopurine sequence next to a cluster of Alu repeated sequences in intron 14

AU - Pauly, Marc

AU - Kayser, Isabelle

AU - Schmitz, Martine

AU - Ries, Fernand

AU - Hentges, François

AU - Dicato, Mario

N1 - Funding Information: We thank Dr. I. Pastan (NIH, Bethesda, MD, USA) and Prof. P. Reizenstein (Karolinska Institute, Stockholm, Sweden) for the gift of probe 5A; Dr. A. Steinmetz, Prof. E. Westhof, J.-M. Garnier and Prof. P. Chambon (CNRS, Strasbourg, France) for the gift of the human genomic library and helpful suggestions. This work was supported by the Centre de Recherche Public de la Sant6 and the Fondation de Recherche Cancer et Sang of Luxembourg.

PY - 1995/2/14

Y1 - 1995/2/14

N2 - In order to identify specific DNA sequences useful as 'genetic landmarks' in the construction of a complete map of the human mdr1 (multidrug-resistance) gene, we investigated the introns in the central region. In intron 14, we identified a long stretch of a homopyrimidine·homopurine sequence most probably adopting an unconventional DNA conformation, followed by a cluster of three Alu repeated sequences in an inverted orientation. Here, we describe the structure, formation and nucleotide sequence of these DNA elements.

AB - In order to identify specific DNA sequences useful as 'genetic landmarks' in the construction of a complete map of the human mdr1 (multidrug-resistance) gene, we investigated the introns in the central region. In intron 14, we identified a long stretch of a homopyrimidine·homopurine sequence most probably adopting an unconventional DNA conformation, followed by a cluster of three Alu repeated sequences in an inverted orientation. Here, we describe the structure, formation and nucleotide sequence of these DNA elements.

KW - P-glycoprotein

KW - gene cloning

KW - gene mapping

KW - nucleotide sequence

KW - recombinant DNA

KW - repetitive sequences

UR - https://www.scopus.com/pages/publications/0028853275

U2 - 10.1016/0378-1119(95)00716-J

DO - 10.1016/0378-1119(95)00716-J

M3 - Article

C2 - 7875611

AN - SCOPUS:0028853275

SN - 0378-1119

VL - 153

SP - 299

EP - 300

JO - Gene

JF - Gene

IS - 2

ER -

The human mdr1 (multidrug-resistance) gene harbours a long homopyrimidine·homopurine sequence next to a cluster of Alu repeated sequences in intron 14

Abstract

Keywords

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