@article{660f1b65506a478a8abb3bd77f6988cc,
title = "The human mdr1 (multidrug-resistance) gene harbours a long homopyrimidine·homopurine sequence next to a cluster of Alu repeated sequences in intron 14",
abstract = "In order to identify specific DNA sequences useful as 'genetic landmarks' in the construction of a complete map of the human mdr1 (multidrug-resistance) gene, we investigated the introns in the central region. In intron 14, we identified a long stretch of a homopyrimidine·homopurine sequence most probably adopting an unconventional DNA conformation, followed by a cluster of three Alu repeated sequences in an inverted orientation. Here, we describe the structure, formation and nucleotide sequence of these DNA elements.",
keywords = "P-glycoprotein, gene cloning, gene mapping, nucleotide sequence, recombinant DNA, repetitive sequences",
author = "Marc Pauly and Isabelle Kayser and Martine Schmitz and Fernand Ries and Fran{\c c}ois Hentges and Mario Dicato",
note = "Funding Information: We thank Dr. I. Pastan (NIH, Bethesda, MD, USA) and Prof. P. Reizenstein (Karolinska Institute, Stockholm, Sweden) for the gift of probe 5A; Dr. A. Steinmetz, Prof. E. Westhof, J.-M. Garnier and Prof. P. Chambon (CNRS, Strasbourg, France) for the gift of the human genomic library and helpful suggestions. This work was supported by the Centre de Recherche Public de la Sant6 and the Fondation de Recherche Cancer et Sang of Luxembourg.",
year = "1995",
month = feb,
day = "14",
doi = "10.1016/0378-1119(95)00716-J",
language = "English",
volume = "153",
pages = "299--300",
journal = "Gene",
issn = "0378-1119",
publisher = "Elsevier",
number = "2",
}