The Histone Methyltransferase DOT1L Is Essential for Humoral Immune Responses

Liam Kealy; Andrea Di Pietro; Lauren Hailes; Sebastian Scheer; Lennard Dalit; Joanna R. Groom; Colby Zaph; Kim L. Good-Jacobson

doi:10.1016/j.celrep.2020.108504

The Histone Methyltransferase DOT1L Is Essential for Humoral Immune Responses

Liam Kealy, Andrea Di Pietro, Lauren Hailes, Sebastian Scheer, Lennard Dalit, Joanna R. Groom, Colby Zaph, Kim L. Good-Jacobson^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

24 Citations (Scopus)

Abstract

B cell differentiation is critical for antibody-mediated clearance of pathogens. Kealy et al. show a key role for the histone modifier DOT1L in B cell responses. DOT1L is essential for appropriate localization of B cells to form germinal centers, the critical sites for producing high-affinity antibody and B cell memory.

Original language	English
Article number	108504
Journal	Cell Reports
Volume	33
Issue number	11
DOIs	https://doi.org/10.1016/j.celrep.2020.108504
Publication status	Published - 15 Dec 2020
Externally published	Yes

Keywords

B cells
DOT1L
H3K79
antibody
epigenetics
humoral responses

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10.1016/j.celrep.2020.108504

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title = "The Histone Methyltransferase DOT1L Is Essential for Humoral Immune Responses",

abstract = "B cell differentiation is critical for antibody-mediated clearance of pathogens. Kealy et al. show a key role for the histone modifier DOT1L in B cell responses. DOT1L is essential for appropriate localization of B cells to form germinal centers, the critical sites for producing high-affinity antibody and B cell memory.",

keywords = "B cells, DOT1L, H3K79, antibody, epigenetics, humoral responses",

author = "Liam Kealy and {Di Pietro}, Andrea and Lauren Hailes and Sebastian Scheer and Lennard Dalit and Groom, {Joanna R.} and Colby Zaph and Good-Jacobson, {Kim L.}",

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AU - Kealy, Liam

AU - Di Pietro, Andrea

AU - Hailes, Lauren

AU - Scheer, Sebastian

AU - Dalit, Lennard

AU - Groom, Joanna R.

AU - Zaph, Colby

AU - Good-Jacobson, Kim L.

PY - 2020/12/15

Y1 - 2020/12/15

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AB - B cell differentiation is critical for antibody-mediated clearance of pathogens. Kealy et al. show a key role for the histone modifier DOT1L in B cell responses. DOT1L is essential for appropriate localization of B cells to form germinal centers, the critical sites for producing high-affinity antibody and B cell memory.

KW - B cells

KW - DOT1L

KW - H3K79

KW - antibody

KW - epigenetics

KW - humoral responses

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DO - 10.1016/j.celrep.2020.108504

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The Histone Methyltransferase DOT1L Is Essential for Humoral Immune Responses

Abstract

Keywords

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