Abstract
B cell differentiation is critical for antibody-mediated clearance of pathogens. Kealy et al. show a key role for the histone modifier DOT1L in B cell responses. DOT1L is essential for appropriate localization of B cells to form germinal centers, the critical sites for producing high-affinity antibody and B cell memory.
Original language | English |
---|---|
Article number | 108504 |
Journal | Cell Reports |
Volume | 33 |
Issue number | 11 |
DOIs | |
Publication status | Published - 15 Dec 2020 |
Externally published | Yes |
Keywords
- B cells
- DOT1L
- H3K79
- antibody
- epigenetics
- humoral responses