@article{152aec3207094d3fb64c590549480a77,
title = "The Histone Methyltransferase DOT1L Is Essential for Humoral Immune Responses",
abstract = "B cell differentiation is critical for antibody-mediated clearance of pathogens. Kealy et al. show a key role for the histone modifier DOT1L in B cell responses. DOT1L is essential for appropriate localization of B cells to form germinal centers, the critical sites for producing high-affinity antibody and B cell memory.",
keywords = "antibody, B cells, DOT1L, epigenetics, H3K79, humoral responses",
author = "Liam Kealy and {Di Pietro}, Andrea and Lauren Hailes and Sebastian Scheer and Lennard Dalit and Groom, {Joanna R.} and Colby Zaph and Good-Jacobson, {Kim L.}",
note = "Funding Information: We thank Mireille Lahoud and David Tarlinton for critical reading of this manuscript; and Good-Jacobson and Zaph labs, Monash Micromon, and Bioinformatics Platforms for technical assistance. This work was supported by Bellberry-Viertel Senior Medical Research and NHMRC Career Development Fellowships ( GNT1108066 ) to K.L.G.-J.; American Association of Immunologists Careers in Immunology Fellowship to A.D.P.; NHMRC project grant GNT1137989 to J.R.G. and K.L.G.-J. and ideas grant GNT1182649 to J.R.G.; WEHI Centenary Fellowship sponsored by CSL to J.R.G.; Monash University Research Training Program Scholarship to L.K.; University of Melbourne Research Scholarship to L.D.; and Veski Innovation Fellowship and NHMRC project grants GNT1104433 and GNT1104466 to C.Z. The graphical abstract was created with BioRender. Funding Information: We thank Mireille Lahoud and David Tarlinton for critical reading of this manuscript; and Good-Jacobson and Zaph labs, Monash Micromon, and Bioinformatics Platforms for technical assistance. This work was supported by Bellberry-Viertel Senior Medical Research and NHMRC Career Development Fellowships (GNT1108066) to K.L.G.-J.; American Association of Immunologists Careers in Immunology Fellowship to A.D.P.; NHMRC project grant GNT1137989 to J.R.G. and K.L.G.-J. and ideas grant GNT1182649 to J.R.G.; WEHI Centenary Fellowship sponsored by CSL to J.R.G.; Monash University Research Training Program Scholarship to L.K.; University of Melbourne Research Scholarship to L.D.; and Veski Innovation Fellowship and NHMRC project grants GNT1104433 and GNT1104466 to C.Z. The graphical abstract was created with BioRender. K.L.G.-J. designed research; L.K. A.D.P. L.H. and L.D. performed research; J.R.G. performed research and provided intellectual input; S.S. and C.Z. provided reagents, mice, and intellectual input; and K.L.G.-J. wrote the manuscript. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = dec,
day = "15",
doi = "10.1016/j.celrep.2020.108504",
language = "English",
volume = "33",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "11",
}