The Gut Microbiota and Hematopoietic Stem Cell Transplantation: Challenges and Potentials

Fozia Noor, Anne Kaysen, Paul Wilmes, Jochen G. Schneider*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Abstract

The human gut microbiota gained tremendous importance in the last decade as next-generation technologies of sequencing and multiomics analyses linked the role of the microbial communities to host physiology and pathophysiology. A growing number of human pathologies and diseases are linked to the gut microbiota. One of the main mechanisms by which the microbiota influences the host is through its interactions with the host immune system. These interactions with both innate and adaptive host intestinal and extraintestinal immunity, although usually commensalistic even mutualistic with the host, in some cases lead to serious health effects. In the case of allogenic hematopoietic stem cell transplantation (allo-HSCT), the disruption of the intestinal microbiota diversity is associated with acute graft-versus-host disease (GvHD). Causing inflammation of the liver, skin, lungs, and the intestine, GvHD occurs in 40-50% of patients undergoing allo-HSCT and results in significant posttransplantation mortality. In this review, we highlight the impact of the gut microbiota on the host immunity in GvHD and the potential of microbiota in alleviation or even prevention of GvHD.

Original languageEnglish
Pages (from-to)405-415
Number of pages11
JournalJournal of Innate Immunity
Volume11
Issue number5
DOIs
Publication statusPublished - 1 Jul 2019
Externally publishedYes

Keywords

  • Graft-versus-host disease
  • Gut microbiota
  • Immune system
  • Microbiome
  • Stem cell transplantation

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