Abstract
Glutathione and the associated enzymes, glutathione S-transferases, peroxidases, and reductase, have been implicated in cancer chemoresistance. This pathway was investigated in paired cancerous and peritumoral breast samples from 41 women. The tumours exhibited a higher redox status as deduced from increased transferase, peroxidase, and reductase activities and from higher total and reduced glutathione contents. Several components were strongly correlated in peritumoral tissues, suggesting a highly co-ordinated glutathione pathway that appeared disrupted in breast tumours with only a few correlations left. Therefore, resistance could spontaneously result from deregulated variations in the glutathione pathway, which might be relevant to the malignant disease progression. (C) 2000 Elsevier Science Ireland Ltd.
Original language | English |
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Pages (from-to) | 7-16 |
Number of pages | 10 |
Journal | Cancer Letters |
Volume | 158 |
Issue number | 1 |
DOIs | |
Publication status | Published - 29 Sept 2000 |
Externally published | Yes |
Keywords
- Breast cancer
- Cancer resistance
- Glutathione system
- Regulation