The glutathione-related detoxification pathway in the human breast: A highly coordinated system disrupted in the tumour tissues

Magali Perquin, Thierry Oster, Armand Maul, Nicolas Froment, Michel Untereiner, Denyse Bagrel*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Abstract

Glutathione and the associated enzymes, glutathione S-transferases, peroxidases, and reductase, have been implicated in cancer chemoresistance. This pathway was investigated in paired cancerous and peritumoral breast samples from 41 women. The tumours exhibited a higher redox status as deduced from increased transferase, peroxidase, and reductase activities and from higher total and reduced glutathione contents. Several components were strongly correlated in peritumoral tissues, suggesting a highly co-ordinated glutathione pathway that appeared disrupted in breast tumours with only a few correlations left. Therefore, resistance could spontaneously result from deregulated variations in the glutathione pathway, which might be relevant to the malignant disease progression. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)7-16
Number of pages10
JournalCancer Letters
Volume158
Issue number1
DOIs
Publication statusPublished - 29 Sept 2000
Externally publishedYes

Keywords

  • Breast cancer
  • Cancer resistance
  • Glutathione system
  • Regulation

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