The Function and Therapeutic Potential of Long Non-coding RNAs in Cardiovascular Development and Disease

Clarissa P.C. Gomes, Helen Spencer, Kerrie L. Ford, Lauriane Y.M. Michel, Andrew H. Baker, Costanza Emanueli, Jean Luc Balligand, Yvan Devaux*, on behalf of the, Cardiolinc network

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

75 Citations (Scopus)

Abstract

The popularization of genome-wide analyses and RNA sequencing led to the discovery that a large part of the human genome, while effectively transcribed, does not encode proteins. Long non-coding RNAs have emerged as critical regulators of gene expression in both normal and disease states. Studies of long non-coding RNAs expressed in the heart, in combination with gene association studies, revealed that these molecules are regulated during cardiovascular development and disease. Some long non-coding RNAs have been functionally implicated in cardiac pathophysiology and constitute potential therapeutic targets. Here, we review the current knowledge of the function of long non-coding RNAs in the cardiovascular system, with an emphasis on cardiovascular development and biology, focusing on hypertension, coronary artery disease, myocardial infarction, ischemia, and heart failure. We discuss potential therapeutic implications and the challenges of long non-coding RNA research, with directions for future research and translational focus.

Original languageEnglish
Pages (from-to)494-507
Number of pages14
JournalMolecular Therapy - Nucleic Acids
Volume8
DOIs
Publication statusPublished - 15 Sep 2017

Keywords

  • RNAs
  • cardiovascular development
  • cardiovascular disease
  • cardiovascular system
  • long non-coding RNAs
  • non-coding RNAs
  • therapy
  • transcriptomics
  • vascular disease

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