TY - JOUR
T1 - The Function and Therapeutic Potential of Long Non-coding RNAs in Cardiovascular Development and Disease
AU - Gomes, Clarissa P.C.
AU - Spencer, Helen
AU - Ford, Kerrie L.
AU - Michel, Lauriane Y.M.
AU - Baker, Andrew H.
AU - Emanueli, Costanza
AU - Balligand, Jean Luc
AU - Devaux, Yvan
AU - on behalf of the
AU - Cardiolinc network
N1 - Funding Information:
C.P.C.G. is funded by the Eurostars E! 9686 MIPROG project. Y.D. is supported by the National Research Fund (grant INTER/EUROSTARS/15/10282117 ) and the Ministry of Higher Education and Research of Luxembourg. A.H.B. is funded by the British Heart Foundation and European Research Council (VASCMIR). C.E. is a BHF Professor in Cardiovascular Science, and her non-coding RNA studies are supported by the BHF and the Leducq Foundation (MIRVAD transatlantic network grant).
Publisher Copyright:
© 2017 The Author(s)
PY - 2017/9/15
Y1 - 2017/9/15
N2 - The popularization of genome-wide analyses and RNA sequencing led to the discovery that a large part of the human genome, while effectively transcribed, does not encode proteins. Long non-coding RNAs have emerged as critical regulators of gene expression in both normal and disease states. Studies of long non-coding RNAs expressed in the heart, in combination with gene association studies, revealed that these molecules are regulated during cardiovascular development and disease. Some long non-coding RNAs have been functionally implicated in cardiac pathophysiology and constitute potential therapeutic targets. Here, we review the current knowledge of the function of long non-coding RNAs in the cardiovascular system, with an emphasis on cardiovascular development and biology, focusing on hypertension, coronary artery disease, myocardial infarction, ischemia, and heart failure. We discuss potential therapeutic implications and the challenges of long non-coding RNA research, with directions for future research and translational focus.
AB - The popularization of genome-wide analyses and RNA sequencing led to the discovery that a large part of the human genome, while effectively transcribed, does not encode proteins. Long non-coding RNAs have emerged as critical regulators of gene expression in both normal and disease states. Studies of long non-coding RNAs expressed in the heart, in combination with gene association studies, revealed that these molecules are regulated during cardiovascular development and disease. Some long non-coding RNAs have been functionally implicated in cardiac pathophysiology and constitute potential therapeutic targets. Here, we review the current knowledge of the function of long non-coding RNAs in the cardiovascular system, with an emphasis on cardiovascular development and biology, focusing on hypertension, coronary artery disease, myocardial infarction, ischemia, and heart failure. We discuss potential therapeutic implications and the challenges of long non-coding RNA research, with directions for future research and translational focus.
KW - RNAs
KW - cardiovascular development
KW - cardiovascular disease
KW - cardiovascular system
KW - long non-coding RNAs
KW - non-coding RNAs
KW - therapy
KW - transcriptomics
KW - vascular disease
UR - http://www.scopus.com/inward/record.url?scp=85029328956&partnerID=8YFLogxK
U2 - 10.1016/j.omtn.2017.07.014
DO - 10.1016/j.omtn.2017.07.014
M3 - Review article
AN - SCOPUS:85029328956
VL - 8
SP - 494
EP - 507
JO - Molecular Therapy - Nucleic Acids
JF - Molecular Therapy - Nucleic Acids
ER -