The emerging role of one-carbon metabolism in T cells

Henry Kurniawan, Takumi Kobayashi (Main author), Dirk Brenner*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

One-carbon metabolism (1CM) supports multiple biological functions, providing 1C units for nucleotide synthesis, epigenetic maintenance, and redox regulation. Although much has been deciphered about the relationship between disruption of 1CM and various diseases, our understanding of 1CM's involvement in the regulation of the immune system is only now evolving. In this review, we summarize key checkpoints of 1CM pathways that govern cellular activities. We also report on recent findings regarding the role of 1CM in T cells and discuss several promising avenues requiring future investigation.

Original languageEnglish
Pages (from-to)193-201
Number of pages9
JournalCurrent Opinion in Biotechnology
Volume68
DOIs
Publication statusPublished - Apr 2021

Fingerprint

Dive into the research topics of 'The emerging role of one-carbon metabolism in T cells'. Together they form a unique fingerprint.

Cite this