The emerging role of one-carbon metabolism in T cells

Henry Kurniawan; Takumi Kobayashi; Dirk Brenner

doi:10.1016/j.copbio.2020.12.001

The emerging role of one-carbon metabolism in T cells

Henry Kurniawan, Takumi Kobayashi (Main author), Dirk Brenner^*

^*Corresponding author for this work

Experimental and Molecular Immunology

Research output: Contribution to journal › Review article › peer-review

15 Citations (Scopus)

Abstract

One-carbon metabolism (1CM) supports multiple biological functions, providing 1C units for nucleotide synthesis, epigenetic maintenance, and redox regulation. Although much has been deciphered about the relationship between disruption of 1CM and various diseases, our understanding of 1CM's involvement in the regulation of the immune system is only now evolving. In this review, we summarize key checkpoints of 1CM pathways that govern cellular activities. We also report on recent findings regarding the role of 1CM in T cells and discuss several promising avenues requiring future investigation.

Original language	English
Pages (from-to)	193-201
Number of pages	9
Journal	Current Opinion in Biotechnology
Volume	68
DOIs	https://doi.org/10.1016/j.copbio.2020.12.001
Publication status	Published - Apr 2021

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10.1016/j.copbio.2020.12.001Licence: CC BY

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title = "The emerging role of one-carbon metabolism in T cells",

abstract = "One-carbon metabolism (1CM) supports multiple biological functions, providing 1C units for nucleotide synthesis, epigenetic maintenance, and redox regulation. Although much has been deciphered about the relationship between disruption of 1CM and various diseases, our understanding of 1CM's involvement in the regulation of the immune system is only now evolving. In this review, we summarize key checkpoints of 1CM pathways that govern cellular activities. We also report on recent findings regarding the role of 1CM in T cells and discuss several promising avenues requiring future investigation.",

author = "Henry Kurniawan and Takumi Kobayashi and Dirk Brenner",

note = "Funding Information: We acknowledge the valuable work of all investigators that we were unable to cite due to space limitations. D.B. and H.K. are supported by the FNR-ATTRACT program ( A14/BM/7632103 ), and D.B. by the FNR-CORE ( C18/BM/12691266 ) and the FNR-PRIDE (PRIDE/11012546/NEXTIMMUNE) scheme. The figures are created using Biorender.com. Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2021",

month = apr,

doi = "10.1016/j.copbio.2020.12.001",

language = "English",

volume = "68",

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AU - Kurniawan, Henry

AU - Kobayashi, Takumi

AU - Brenner, Dirk

N1 - Funding Information: We acknowledge the valuable work of all investigators that we were unable to cite due to space limitations. D.B. and H.K. are supported by the FNR-ATTRACT program ( A14/BM/7632103 ), and D.B. by the FNR-CORE ( C18/BM/12691266 ) and the FNR-PRIDE (PRIDE/11012546/NEXTIMMUNE) scheme. The figures are created using Biorender.com. Publisher Copyright: © 2020 The Authors

PY - 2021/4

Y1 - 2021/4

N2 - One-carbon metabolism (1CM) supports multiple biological functions, providing 1C units for nucleotide synthesis, epigenetic maintenance, and redox regulation. Although much has been deciphered about the relationship between disruption of 1CM and various diseases, our understanding of 1CM's involvement in the regulation of the immune system is only now evolving. In this review, we summarize key checkpoints of 1CM pathways that govern cellular activities. We also report on recent findings regarding the role of 1CM in T cells and discuss several promising avenues requiring future investigation.

AB - One-carbon metabolism (1CM) supports multiple biological functions, providing 1C units for nucleotide synthesis, epigenetic maintenance, and redox regulation. Although much has been deciphered about the relationship between disruption of 1CM and various diseases, our understanding of 1CM's involvement in the regulation of the immune system is only now evolving. In this review, we summarize key checkpoints of 1CM pathways that govern cellular activities. We also report on recent findings regarding the role of 1CM in T cells and discuss several promising avenues requiring future investigation.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/33422815

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DO - 10.1016/j.copbio.2020.12.001

M3 - Review article

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SN - 0958-1669

VL - 68

SP - 193

EP - 201

JO - Current Opinion in Biotechnology

JF - Current Opinion in Biotechnology

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The emerging role of one-carbon metabolism in T cells

Abstract

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