The emerging role of miR-653 in human cancer

Moussa Omorou; Yiwei Huang; Ning Liu; Solim Essomandan Clémence Bafei; Meng Gao; Chenxi Mu; Lin Zhang; Xu Hui

doi:10.1016/j.canep.2022.102208

The emerging role of miR-653 in human cancer

Moussa Omorou^*, Yiwei Huang, Ning Liu, Solim Essomandan Clémence Bafei, Meng Gao, Chenxi Mu, Lin Zhang, Xu Hui^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) refer to a family of non-coding RNA with ~22 nucleotides in length. A high number of studies show evidence that deregulation in miRNAs expression could be implicated in the processes of many pathologies such as cancer, hypoxia, and stroke. Herein, we aimed to summarize the miR-653 expression level and molecular mechanisms through which it functions in human cancer. It was found that variations in miR-653 expression are linked to tumor aggressiveness and unfavorable prognosis in human cancer, and it plays an inhibitory effect in some types of cancer, such as breast, cervical, liver, renal, and lung cancers. In contrast, it plays an acceleratory impact in some other cancers, such as bladder and prostate cancers. In gastric cancer, the role played by miR-653 is still controversial and will need to be elucidated in future studies. Future studies could definitely establish targeting miR-653 as a novel strategy in human cancer, from diagnosis to effective treatment.

Original language	English
Article number	102208
Journal	Cancer Epidemiology
Volume	79
DOIs	https://doi.org/10.1016/j.canep.2022.102208
Publication status	Published - Aug 2022
Externally published	Yes

Keywords

Apoptosis
Cancer
Metastasis
MiR-653

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@article{eddaf4f9c38945d1be526106fdf4565c,

title = "The emerging role of miR-653 in human cancer",

abstract = "MicroRNAs (miRNAs) refer to a family of non-coding RNA with ~22 nucleotides in length. A high number of studies show evidence that deregulation in miRNAs expression could be implicated in the processes of many pathologies such as cancer, hypoxia, and stroke. Herein, we aimed to summarize the miR-653 expression level and molecular mechanisms through which it functions in human cancer. It was found that variations in miR-653 expression are linked to tumor aggressiveness and unfavorable prognosis in human cancer, and it plays an inhibitory effect in some types of cancer, such as breast, cervical, liver, renal, and lung cancers. In contrast, it plays an acceleratory impact in some other cancers, such as bladder and prostate cancers. In gastric cancer, the role played by miR-653 is still controversial and will need to be elucidated in future studies. Future studies could definitely establish targeting miR-653 as a novel strategy in human cancer, from diagnosis to effective treatment.",

keywords = "Apoptosis, Cancer, Metastasis, MiR-653",

author = "Moussa Omorou and Yiwei Huang and Ning Liu and Bafei, {Solim Essomandan Cl{\'e}mence} and Meng Gao and Chenxi Mu and Lin Zhang and Xu Hui",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = aug,

doi = "10.1016/j.canep.2022.102208",

language = "English",

volume = "79",

journal = "Cancer Epidemiology",

issn = "1877-7821",

publisher = "Elsevier Ltd.",

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T1 - The emerging role of miR-653 in human cancer

AU - Omorou, Moussa

AU - Huang, Yiwei

AU - Liu, Ning

AU - Bafei, Solim Essomandan Clémence

AU - Gao, Meng

AU - Mu, Chenxi

AU - Zhang, Lin

AU - Hui, Xu

PY - 2022/8

Y1 - 2022/8

N2 - MicroRNAs (miRNAs) refer to a family of non-coding RNA with ~22 nucleotides in length. A high number of studies show evidence that deregulation in miRNAs expression could be implicated in the processes of many pathologies such as cancer, hypoxia, and stroke. Herein, we aimed to summarize the miR-653 expression level and molecular mechanisms through which it functions in human cancer. It was found that variations in miR-653 expression are linked to tumor aggressiveness and unfavorable prognosis in human cancer, and it plays an inhibitory effect in some types of cancer, such as breast, cervical, liver, renal, and lung cancers. In contrast, it plays an acceleratory impact in some other cancers, such as bladder and prostate cancers. In gastric cancer, the role played by miR-653 is still controversial and will need to be elucidated in future studies. Future studies could definitely establish targeting miR-653 as a novel strategy in human cancer, from diagnosis to effective treatment.

AB - MicroRNAs (miRNAs) refer to a family of non-coding RNA with ~22 nucleotides in length. A high number of studies show evidence that deregulation in miRNAs expression could be implicated in the processes of many pathologies such as cancer, hypoxia, and stroke. Herein, we aimed to summarize the miR-653 expression level and molecular mechanisms through which it functions in human cancer. It was found that variations in miR-653 expression are linked to tumor aggressiveness and unfavorable prognosis in human cancer, and it plays an inhibitory effect in some types of cancer, such as breast, cervical, liver, renal, and lung cancers. In contrast, it plays an acceleratory impact in some other cancers, such as bladder and prostate cancers. In gastric cancer, the role played by miR-653 is still controversial and will need to be elucidated in future studies. Future studies could definitely establish targeting miR-653 as a novel strategy in human cancer, from diagnosis to effective treatment.

KW - Apoptosis

KW - Cancer

KW - Metastasis

KW - MiR-653

UR - http://www.scopus.com/inward/record.url?scp=85133559540&partnerID=8YFLogxK

U2 - 10.1016/j.canep.2022.102208

DO - 10.1016/j.canep.2022.102208

M3 - Review article

C2 - 35777307

AN - SCOPUS:85133559540

SN - 1877-7821

VL - 79

JO - Cancer Epidemiology

JF - Cancer Epidemiology

M1 - 102208

ER -

The emerging role of miR-653 in human cancer

Abstract

Keywords

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