The DNA Damage Response in Fully Grown Mammalian Oocytes

Alexandros Pailas, Konstantina Niaka, Chrysoula Zorzompokou, Petros Marangos*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

DNA damage in cells can occur physiologically or may be induced by exogenous factors. Genotoxic damage may cause cancer, ageing, serious developmental diseases and anomalies. If the damage occurs in the germline, it can potentially lead to infertility or chromosomal and genetic aberrations in the developing embryo. Mammalian oocytes, the female germ cells, are produced before birth, remaining arrested at the prophase stage of meiosis over a long period of time. During this extensive state of arrest the oocyte may be exposed to different DNA-damaging insults for months, years or even decades. Therefore, it is of great importance to understand how these cells respond to DNA damage. In this review, we summarize the most recent developments in the understanding of the DNA damage response mechanisms that function in fully grown mammalian oocytes.

Original languageEnglish
Article number798
JournalCells
Volume11
Issue number5
DOIs
Publication statusPublished - 24 Feb 2022
Externally publishedYes

Keywords

  • Checkpoints
  • DNA damage response
  • DNA repair
  • Oocyte

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