TY - JOUR
T1 - The DNA Damage Response in Fully Grown Mammalian Oocytes
AU - Pailas, Alexandros
AU - Niaka, Konstantina
AU - Zorzompokou, Chrysoula
AU - Marangos, Petros
N1 - Funding Information:
K.N. is funded by the Hellenic Foundation for Research and Innovation (HFRI) under the HFRI PhD Fellowship grant (Fellowship Number: 440). C.Z. is funded by Greece and the European Union through the European Regional Development Fund (ERDF) under the Operational Program “Competitiveness Entrepreneurship Innovation” (EPAnEK), NSRF 2014-2020 (MIS 5047236).
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/2/24
Y1 - 2022/2/24
N2 - DNA damage in cells can occur physiologically or may be induced by exogenous factors. Genotoxic damage may cause cancer, ageing, serious developmental diseases and anomalies. If the damage occurs in the germline, it can potentially lead to infertility or chromosomal and genetic aberrations in the developing embryo. Mammalian oocytes, the female germ cells, are produced before birth, remaining arrested at the prophase stage of meiosis over a long period of time. During this extensive state of arrest the oocyte may be exposed to different DNA-damaging insults for months, years or even decades. Therefore, it is of great importance to understand how these cells respond to DNA damage. In this review, we summarize the most recent developments in the understanding of the DNA damage response mechanisms that function in fully grown mammalian oocytes.
AB - DNA damage in cells can occur physiologically or may be induced by exogenous factors. Genotoxic damage may cause cancer, ageing, serious developmental diseases and anomalies. If the damage occurs in the germline, it can potentially lead to infertility or chromosomal and genetic aberrations in the developing embryo. Mammalian oocytes, the female germ cells, are produced before birth, remaining arrested at the prophase stage of meiosis over a long period of time. During this extensive state of arrest the oocyte may be exposed to different DNA-damaging insults for months, years or even decades. Therefore, it is of great importance to understand how these cells respond to DNA damage. In this review, we summarize the most recent developments in the understanding of the DNA damage response mechanisms that function in fully grown mammalian oocytes.
KW - Checkpoints
KW - DNA damage response
KW - DNA repair
KW - Oocyte
UR - http://www.scopus.com/inward/record.url?scp=85125227209&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/35269420
U2 - 10.3390/cells11050798
DO - 10.3390/cells11050798
M3 - Review article
C2 - 35269420
AN - SCOPUS:85125227209
SN - 2073-4409
VL - 11
JO - Cells
JF - Cells
IS - 5
M1 - 798
ER -