@article{f9ce55e3130b4cc699609acaa1078b2b,
title = "The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila",
abstract = "Drosophila, like other invertebrates and plants, relies mainly on RNA interference for its defense against viruses. In flies, viral infection also triggers the expression of many genes. One of the genes induced, Vago, encodes a 18-kilodalton cysteine-rich polypeptide. Here we provide genetic evidence that the Vago gene product controlled viral load in the fat body after infection with drosophila C virus. Induction of Vago was dependent on the helicase Dicer-2. Dicer-2 belongs to the same DExD/ H-box helicase family as do the RIG-I-like receptors, which sense viral infection and mediate interferon induction in mammals. We propose that this family represents an evolutionary conserved set of sensors that detect viral nucleic acids and direct antiviral responses.",
author = "Safia Deddouche and Nicolas Matt and Aidan Budd and Stefanie Mueller and Cordula Kemp and Delphine Galiana-Arnoux and Catherine Dostert and Christophe Antoniewski and Hoffmann, {Jules A.} and Imler, {Jean Luc}",
note = "Funding Information: We thank E. Santiago and S. Ozkan for technical expertise; R. Carthew (Northwestern University), J.-M. Reichhart (Unit{\'e} Propre de Recherch{\'e} 9022 Centre National de la Recherche Scientifique) and M. Siomi (University of Tokushima) for fly stocks; A. Schneeman (The Scripps Research Institute) for FHV and anti-FHV; D. Ferrandon for critical reading of the manuscript and comments; and E. Levashina for discussions. Confocal microscopy was done at the Strasbourg Esplanade Cellular Imaging Facility (funded by the Centre National de la Recherche Scientifique, Institut National de la Sant{\'e} et de la Recherche M{\'e}dicale, Louis Pasteur University and Alsace Region). Supported by the US National Institutes of Health (PO1 AI070167), Agence Nationale de Recherche Microbiologie-Maladie Emergentes and Centre National de la Recherche Scientifique.",
year = "2008",
doi = "10.1038/ni.1664",
language = "English",
volume = "9",
pages = "1425--1432",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Publishing Group",
number = "12",
}